Shanghai Huali Integrated Circuit Corporation

Jecho Laboratories Inc.

Jecho Institute, Co., Ltd.

Shanghai Jiao Tong University

Jecho Biopharmaceuticals Co Ltd.

Junsheng Chen

Hua Jiang

Lei Han

Zhenan Lai

Jing Wang

Jianwei Zhu

Yueqing Xie

Lei Zhang

Huili Lu

Zhaoying Huang

Kai Ding

Baohong Zhang

Huifang Zong

A polypeptide composition, and methods of making the same, may include a first polypeptide and a second polypeptide, wherein the first polypeptide comprise a first toxin fragment and a first intein fragment, the second polypeptide comprise a second toxin fragment and a second intein fragment, the first polypeptide is different from the second polypeptide; the first toxin fragment and the second toxin fragment are non-biotoxic; the first polypeptide and the second polypeptide may make the first toxin fragment and the second toxin fragment into biotoxic toxins by an interaction of the first intein fragment and the second intein fragment. Kits may include such first and second polypeptides, and such compositions and kits may be used in treating tumors.

Polypeptide composition

Provided is a polypeptide combination, a targeting component thereof comprising a shielding peptide, a cleavable part, an antigen-binding part and a first intein fragment, the shielding peptide and the antigen-binding part being connected by means of the cleavable part, and the antigen-binding part being directly or indirectly connected to the first intein fragment; a toxin component thereof comprises a second intein fragment and a toxin, and the second intein fragment is directly or indirectly connected to the toxin; the targeting component and the toxin component form an immunoconjugate by means of the interactive action between the first intein fragment and the second intein fragment; in the immunoconjugate, the shielding peptide and the antigen-binding part are connected by means of the cleavable part, and the antigen-binding part is connected to the toxin. Also provided are a preparation method and a pharmaceutical use for the polypeptide combination.

Polypeptide combination used for tumour immunotherapy, and preparation method therefor

The present application discloses a design for testability circuit of an SRAM. In a write path circuit detection mode of a fault diagnosis logic control module, a write path circuit is in an on state, a write data bit multiplexer is in a selected state, a read data bit multiplexer is in a deselected state, a read path circuit is in an on state, and a memory cell is in a selected state; in a read path circuit detection mode, the write path circuit is in an off state, the write data bit multiplexer is in a selected state, the read data bit multiplexer is in a deselected state, the read path circuit is in an on state, and the memory cell is in a deselected state. A bit line signal end is connected to a test signal outputted by a signal generation circuit.

Testability circuit and read and write path decoupling circuit of SRAM

A design-for-test circuit for evaluating a BTI effect is disclosed, the circuit includes a number of stress generators having logic circuits with input and output terminals. Each output terminal is connected to the grid of the device to be tested. In a stress mode, a stress input signal is selected from a frequency signal, a first direct current voltage, and a second direct current voltage, all stress output signals formed by all the stress generators comprise the first direct current voltage, a series of frequency signals with different duty cycles, and the second direct current voltage, and all the stress output signals are used in combination such that the stress times regarding the device under test within the same test time have different values, so as to evaluate the BTI effect of the device under test which has different values of the stress times.

Circuit for temperature stress test for memory chips

The present disclosure discloses a method for expressing and preparing a bivalent bispecific antibody. In the present disclosure, each portion of a bivalent bispecific antibody and an immune hybrid protein thereof is respectively expressed in a suitable prokaryotic or eukaryotic cell system, separated and purified by high-performance affinity chromatography, and then spliced in vitro by trans-splicing reaction mediated by an intein, to prepare the bivalent specific antibody and an immune hybrid protein thereof.

Bivalent bispecific antibody hybrid protein expression and preparation methods

The disclosure discloses a wafer acceptance test module for a static memory function test, reduced instruction built-in self-test circuit formed on a wafer includes: a ring oscillator, a frequency divider, a counter, a data latch and comparator. The counter is used for count, and the count is used as an input signal of each of an address decoder and a data input port at the same time. The data latch and comparator is connected to an output terminal of the address decoder and an output terminal of the sense amplifier and compare two output signals to obtain a test result. The disclosure also discloses a wafer acceptance test method for a static memory function test. The disclosure does not need to rely on a dedicated test machine for memory to perform a static memory function test, which can simplify a test procedure.

Wafer acceptance test module and method for a static memory function test

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Shanghai, China

Junsheng Chen