Wakunaga Pharmaceutical Co., Ltd.

Junpei Yamashita

Akira Yazaki

Kenji Itoh

Tatsuya Hirano

Rumiko Shimabara

Yohei Kawakubo

Tomonori Yamaguchi

Masayuki Sato

Taichi Ueshima

It is intended to provide a novel compound having high antitumor activity and low toxicity to normal cells. The present invention provides a pyridone carboxylic acid derivative represented by the following formula (1) or a salt thereof wherein Rrepresents a hydrogen atom, a halogen atom or the like; Rrepresents a hydrogen atom, a halogen atom or the like; Rto Reach represent a hydrogen atom or the like; Rrepresents a hydrogen atom or the like; Rrepresents a hydrogen atom, a halogen atom, the following formula (a) (wherein Rand Reach represent a hydrogen atom, a hydroxy group, an optionally substituted lower alkyl group or the like) or the like, or Rand Rtogether represent &#x2550;N&#x2014;OR(wherein Rrepresents a hydrogen atom, an optionally substituted lower alkyl group, or an aralkyl group), or Rand Rform an optionally substituted 4- to 6-membered saturated hetero ring together with the adjacent carbon atom, or the like; Rrepresents a hydrogen atom or the like; X represents a nitrogen atom or the like; and Y represents a nitrogen atom or the like. 

Pyridone carboxylic acid derivative or salt thereof

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Akitakata, Japan

Junpei Yamashita