Theravance, Inc.

Theravance Biopharma Antibiotics Ip, LLC

Thervance, Inc.

Junning Lee

Jyanwei Liu

Martin Sheringham Linsell

Michael Robert Leadbetter

Weijiang Zhang

Mathai Mammen

Miroslav Rapta

David A Oare

Pierre-Jean Colson

Robert S Chao

Daniel G Genov

Michael Robert Tracey

Dimitar Filipov

Ronnie Cheung

Jack Green

Matthew J Peterson

Richard J Lee

The present invention relates to a compound of formula I: 

Hydrochloride salts of a glycopeptide-cephalosporin antbiotic compond

The invention relates to a crystalline form of a triethylamine salt of (2Z)-2-(2 -amino-5-chlorothiazol-4-yl)-2-(3-N-tert-butoxycarbonylaminopropoxyimino)acetic acid. The invention also relates to processes and intermediates for preparing the crystalline form. The crystalline form is useful as an intermediate for preparing cross-linked glycopeptide-cephalosporin antibiotics.

Crystalline form of a substituted thiazolylacetic acid triethylamine salt

Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without isolation of intermediate reaction products, thereby generating less waste and improving the overall efficiency and yield of the process.

Process for preparing glycopeptide phosphonate derivatives

This invention provides 4-amino-1-(pyridylmethyl)piperidine and related compounds and pharmaceutically acceptable salts thereof which are useful as muscarinic receptor antagonists. This invention also provides pharmaceutical compositions containing such compounds; processes and intermediates useful for preparing such compounds; and methods for treating disease conditions mediated by muscarinic receptors, such as overactive bladder, irritable bowel syndrome and chronic obstructive pulmonary disease, using such compounds.

Substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds

Disclosed are hydrochloride salts of telavancin having a chloride ion content of from about 2.4 wt. % to about 4.8 wt. %. The disclosed salts have improved stability during storage at ambient temperatures compared to other hydrochloride salts. Also disclosed are processes for preparing such salts.

Hydrochloride salts of a glycopeptide phosphonate derivative

The invention provides 8-azabicyclo[3.2.1 ]octyl intermediates useful for the preparation of 5-HTreceptor agonist compounds. The invention also provides processes for the preparation of such useful intermediates.

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Processes and intermediates for preparing substituted 4-amino-1-(pyridylmethyl)-piperidine and related compounds in high yield and high purity are described. The substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds prepared by the described processes are useful as muscarinic receptor antagonists.

Process for preparing substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds

The invention provides a crystalline naphthalene-1,5-disulfonic acid salt of biphenyl-2-ylcarbamic acid 1-{9-[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydro-quinolin-5 -yl)ethylamino]nonyl}piperidin-4-yl ester or a solvate thereof. This invention also provides pharmaceutical compositions comprising such a salt or prepared using such a salt; processes and intermediates for preparing such a salt; and methods of using such a salt to treat a pulmonary disorder.

Crystalline form of a biphenyl compound

Disclosed are processes for preparing glycopeptide antibiotic derivatives having an amino-containing side chain. The multi-step process is conducted in a single reaction vessel without isolation of intermediate reaction products.

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El Granada, CA, United States of America

Junning Lee