Shijiazhuang Sagacity New Drug Development Company, Ltd.

Medshine Discovery Inc.

Chinese Pla General Hospital

Wuxi Biocity Biopharmaceuticals Co., Ltd.

Wuxi Biocity Biopharmaceutics Co., Ltd.

Junmiao Li

Yunfu Luo

Maoyi Lei

Shuhui Chen

Yu Xu

Xin Li

Chen Bo Li

Chen Li

Kunlun He

Chunlei Liu

Guoli Zhang

Jinghong Dong

Zeyu Zhang

Ran Wei

Xiaojian Gao

Yiwei Wang

Disclosed are a Crystal Form (I) of a pyrimidine sulfonamide compound and a preparation method therefor. The present disclosure relates to an application thereof in the preparation of a medicament for treating diseases related to ETreceptor antagonists.

Crystal form of pyrimidine sulfonamide compound and preparation method therefor

A compound represented by formula (III) or a pharmaceutically acceptable salt thereof, and disclosed is an application thereof in the preparation of a medication for treating diseases related to a CRBN receptor.

Bicyclic compound that acts as CRBN protein regulator

The present disclosure provides application of a compound in conformity with a general formula I and an isomer or pharmaceutically acceptable salt thereof to preparation of a medicinal composition for treating or preventing a high altitude disease. The high altitude disease is selected from an acute high altitude disease and a chronic high altitude disease generated in a high altitude environment with an altitude of 2,000 m or above.

Medical application of pyrimidine sulfonamides derivatives

Disclosed are a series of pyrimidine sulfamide compounds and applications thereof in preparing a drug for a disease related to an ETreceptor antagonist. In particular, disclosed is a derived compound represented by formula (I) or a tautomer or pharmaceutically acceptable composition thereof. 

Pyrimidine sulfamide derivative and preparation method and medical application thereof

Growing community of inventors

Shanghai, China

Junmiao Li