Hoffmann-La Roche Inc.

Junko Watanabe

Raffaello Masciadri

Helmut Link

Erwin Gotschi

Hisao Shimada

Mikio Arisawa

Tsutomu Kamiyama

Paul Hebeisen

Paulfaello Hebeisen

Bicyclic derivatives of the general formula ##STR1## wherein X.sup.1 is --S-- or --SO--;

Process for the preparation of DNA gyrase inhibitors

Compounds of the formula ##STR1## in which P is hydroxy and T is the group -X.sup.2 -CR.sup.7a R.sup.7b -CHR.sup.8 -OH or T is hydrogen and P is the group O-CHR.sup.8 -CR.sup.7a R.sup.7b -X.sup.2 -OH and, wherein X.sup.1, X.sup.2, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7a, R.sup.7b, and R.sup.8 are as defined in the specification, or a reactive derivative thereof. These compounds are useful in the preparation of DNA gyrase inhibitors.

DNA gyrase inhibitors, process for their manufacture and pharmaceutical

DNA gyrase inhibitors and pharmaceutical preparations therefor

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Yokohama, Japan

Junko Watanabe