Nippon Mining Co., Ltd.

Japan Energy Corporation

Junko Umezawa

Osamu Takahashi

Yoshiaki Isobe

Yuso Goto

Keizo Furuhashi

Hideharu Sato

Fumihiro Obara

Toshimasa Katagiri

Nobuo Watanabe

Masashi Sasaki

The present invention relates to 1-arylpyrimidine derivatives represented by general formula (I): ##STR1## wherein R.sub.1 is H, alkyl or aralkyl;

1-arylpyrimidine derivatives and pharmaceutical use thereof

Pentafluorophenyl derivatives are expressed by the formula (I): ##STR1## where X represents an alkyl group having from 1 to 4 carbon atoms or a halogen atom; Y represents any group of --CH.sub.2 OH, --COOH, --COCl, --CON.sup.1 R.sup.2, or --OSO.sub.2 R.sup.3 ; R.sup.1, R.sup.2 and R.sup.3 represent an alkyl group which may have a substituted group, an aryl group which may have a substituted group, or a hydrogen atom except for R.sup.3. However, when X to a halogen atom, Y is the aforementioned groups other than --OSO.sub.2 R.sup.3. A racemate and/or an optical active form of the pentafluorophenyl derivatives can be used suitably as derivatizing agents for electron capture detection and optical resolution for analysis and as intermediates for medicines, agricultural chemicals, functional polymers, etc. The pentafluorophenyl derivatives are produced from pentafluorostyrene oxide.

Pentafluorophenyl derivatives, methods of production thereof, and method

Growing community of inventors

Toda, Japan

Junko Umezawa