Mitsubishi Kasei Corporation

Junko Hayashi

Tetsuro Shimpuku

Asami Seino

Tetsuo Sekiya

Tatsuo Nagano

Mikio Tsutsui

Akihiro Tobe

Hiromi Okushima

Makio Kobayashi

Hideki Bessho

The .beta.-oxo-.beta.-benzenepropanethioamide derivative of the present invention has potassium channel opening action and is useful for treatment of hypertension, asthma, hypersensitive colon syndrome, and enteritis through pharmacological actions including blood vessel dilation, bronchial tract dilation, relaxation of gastrointestinal tract smooth muscle, and the like. The present invention also includes a pharmaceutical composition containing, as the active ingredient, the compound of the present invention and a method for producing the same.

Imidazoyl-.beta.-oxo-.beta.-benzenepropanethiomide derivative,

.beta.-oxo-.beta.-benzenepropanethioamide compounds

Disclosed are antihypertensive pharmaceutical compositions and compounds which include the thiocarbamoylacetonitrile having the formula: ##STR1## wherein: R.sup.1 is selected from the group consisting of hydrogen, a C.sub.1 to C.sub.6 alkyl, a C.sub.3 to C.sub.6 cycloalkyl or --(CH.sub.2).sub.n --A (where A is selected from the group consisting of a C.sub.6 to C.sub.12 aryl, a 5- or 6-membered heterocyclic group or a fused heterocyclic group constituted by 9 or 10 atoms, each of which may be substituted by at least one substitute group selected from a C.sub.1 to C.sub.6 alkyl and a halogen and n is 0 or an integer of 1 to 6),

Antihypertensive thiocarbamoylascetonitrile compounds

Growing community of inventors

Tokyo, Japan

Junko Hayashi