Mitsubishi Tanabe Pharma Corporation

Junki Ando

Tetsuo Yamaguchi

Takafumi Yamagami

Takao Teshima

Hiroyuki Furukawa

Maiko Hamada

Naoto Fujie

Hiroyuki Ushio

Tooru Takashima

Atsushi Numata

Masayuki Watanabe

The present invention provides a process for preparing a compound represented by formula (VII), which comprises reacting a compound represented by formula (VI) with a malonic acid derivative in the presence of a base and an asymmetric catalyst in a two layer solvent system of hydrophobic solvent and water, (wherein Rand Reach independently represents a protecting group for carboxyl group).

Method for producing optically active pyrrolidine compounds

The present invention provides a process for preparing a compound represented by formula (VII), which comprises reacting a compound represented by formula (VI) with a malonic acid derivative in the presence of a base and an asymmetric catalyst in a two layer solvent system of hydrophobic solvent and water. (wherein Rand Reach independently represents a protecting group for carboxyl group).

The present invention relates to a novel amide derivative. More specifically, the present invention provides a medicinal agent useful as a prophylactic or therapeutic agent for diseases, which relies on the production of cytokines from T cells, and which comprises an amide derivative or a pharmacologically acceptable salt thereof or a solvate of the derivative or the pharmacologically acceptable salt as an active ingredient. Provided is an amide derivative represented by general formula (I) [wherein each symbol is as defined in the description] or a pharmacologically acceptable salt thereof, or a solvate of the derivative or the pharmacologically acceptable salt.

Amide derivative and use thereof

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Osaka, Japan

Junki Ando