Other

Tohoku University

Yamasa Corporation

Junken Aoki

Kimiko Murofushi

Mari Gotoh

Asuka Inoue

Keiko Fukasawa

Motoki Hoshina

Atsushi Kawasaki

Kouki Kawakami

Provided herein is a method and kit that accurately measure autoantibody activity against a TSH receptor without pretreating a blood sample. The autoantibody activity against a TSH receptor in a blood sample is measured by using a kit for measurement of autoantibody activity against a TSH receptor in a mammal cell, comprising a mammal cell expressing both a cAMP biosensor and the TSH receptor, and a substrate capable of visualizing and/or quantifying the CAMP biosensor as constituents, and performing the steps of: (a) incubating a mammal cell expressing both a cAMP biosensor and the TSH receptor in the presence of a blood sample collected from a test subject; (b) measuring an activation level of the CAMP biosensor after the step (a); and (c) comparing the activation level measured in the step (b) with an activation level in a control to calculate the autoantibody activity.

Method and kit for rapid measurement of autoantibody activity with respect to TSH receptor

It is an object of the present invention to identify a novel analog of carbacyclic phosphatidic acid that is a cyclic phosphatidic acid derivative, and to clarify the physiological activity thereof. According to the present invention, a compound represented by the following formula (1) is provided:

Carbalysophosphatidic acid

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Miyagi, Japan

Junken Aoki