The University of Texas System

Fred Hutchinson Cancer Center

Fred Hutchinson Cancer Research Center

Junke Zheng

Mi Deng

Chengcheng Zhang

Zhiqiang An

Ningyan Zhang

Wei Xiong

Xun Gui

Chuo Chen

Irwin D Bernstein

Jiawei Liu

Zhigang Lu

Yi Liu

The present disclosure is directed to antibodies binding to LILRBs and methods of detecting and treating cancer therewith.

Anti-LILRB antibodies and their use in detecting and treating cancer

The present disclosure relates to methods of using a compound to induce regeneration of hematopoietic stem cells or increase the recovery of red blood cells. In some aspects, the present methods can be used to with or in place of erythropoietin in patients to mitigate the side effects of erythropoietin.

Compounds supports hematopoietic stem cells and red blood cells

The current disclosure describes methods of expanding precursor cells for hematopoietic transplantation in subjects. The methods culture precursor cells in media containing an immobilized high molecular weight LILRB2 agonist or an LILRB2 agonist in combination with a Notch agonist. The expanded cells can be used to treat a variety of hematopoietic disorders.

LILRB2 and notch-mediated expansion of hematopoietic precursor cells

Growing community of inventors

Shanghai, China

Junke Zheng