Beijing Institute of Technology

Beijing Dongfang Biotech Co., Ltd.

Beijing Jingyitaixiang Technology Development Co. Ltd.

Junjie Zhou

Chao Wei

Wei Wu

Yi Bai

Xiaomin Li

Haiping Zhou

Xianhong Bai

Yanlu Zan

Shuang Pei

Jibin Hu

Chongbo Jing

Zengxiong Peng

Some embodiments of the disclosure provide a three-section hydraulic mechanical compound stepless transmission device which utilizes the compounding of a hydraulic speed control circuit and a mechanical circuit. According to an embodiment, a three-section hydraulic mechanical stepless transmission device for a loader includes a casing, a hydraulic speed control circuit, an ahead and astern mechanism, a split-collecting mechanism, a hydraulic section fixed shaft gear transmission system, a first hydraulic mechanical section fixed shaft gear transmission system, a second hydraulic mechanical section fixed shaft gear transmission system, and an output portion. According to another embodiment, the three-section hydraulic mechanical compound stepless transmission device includes a hydraulic circuit which transmits only part of power.

Three-section hydraulic mechanical stepless transmission device for loader

The invention provides human monoclonal antibodies that specifically bind to PD-1 with high affinity. The anti-PD-1 monoclonal antibodies were screened from a synthetic antibody library, and affinity maturation was performed. The synthetic antibody libraries used to select for the high affinity anti-PD-1 monoclonal antibodies were made by replacing the light chain CDR1, CDR2 and CDR3 and heavy chain CDR1, CDR 2 and CDR 3 of phage libraries from the preliminary screening, and the high affinity anti-PD-1 monoclonal antibodies were selected. The human anti-PD-1 monoclonal antibodies have high affinity and inhibit the binding of PD-1 to its ligand PD-L1. The antibodies can be used for treating tumor, inflammation and autoimmune diseases.

Anti-PD-1 monoclonal antibody and obtaining method therefor

Growing community of inventors

Beijing, China

Junjie Zhou