Taiho Pharmaceutical Company Limited

Junji Yamamoto

Nobuo Kasahara

Makoto Kajitani

Mitsugi Yasumoto

Akihiro Kawaguchi

Kazuo Ogawa

Ichiro Yamawaki

Masato Nanri

Takashi Arima

Manabu Kaneda

Etsuo Hasegawa

Takaji Honna

Katsuo Toide

Atsushi Satoh

Atsushi Sato

Bicyclolactam compounds, use thereof and intermediates for preparing thereof

Bicycloloactam compounds, use thereof and intermediates for preparing thereof

A bicyclolactam compound of the formula (1) is disclosed, which has an excellent anxiolytic effect, is high in safety, and is useful as an effective component of medicinals which are greatly diminished in side effects such as hypnotic, muscle relaxant and sedative effects ##STR1## A bicyclolactam derivative represented by the following formula (1) is also disclosed, and is useful as an effective component of an anxiolytic agent ##STR2##

Bicyclolactam compounds, use thereof and intermediates for preparing

A bicyclolactam compound of the formula (1) is disclosed, which has an excellent anxiolytic effect, is high in safety, and is useful as an effective component of medicinals which are greatly diminished in side effects such as hypnotic, muscle relaxant and sedative effects ##STR1## A bicyclolactam derivative represented by the following formula (1) is also disclosed, and is useful as an effective component of an anxiolytic agent ##STR2## .

The present invention provides carbamoyl-2 -pyrrolidinone compounds useful as medicaments for improving cerebral functions and activating cerebral metabolism or protecting against anoxic brain damage.

Carbamoyl-2-pyrrolidinone compounds

The present invention provides a bicyclolactam derivative which has the following formula and is useful as medicaments for treating senile dementia, i.e., as cerebral function improving agents and cerebral metabolism activators or anoxic brain damage protectives ##STR1## wherein R is benzoyl group which may be substituted with halogen atom, lower alkyl group, lower alkoxyl group, nitro group, cyano group or amino group; l is 1 or 2; m is 0 or 1; and n is 0, 1 or 2, provided that m and n are not 0 at the same time.

Bicyclolactam derivative for improving cerebral function

Oxindole derivative

Pharmaceutically useful bicyclolactam derivative

Diazabicycloalkane derivative

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Tokushima, Japan

Junji Yamamoto