Otsuka Pharmaceutical Company, Limited

Otsuka Chemical Co., Ltd.

Junji Takaba

Yusuke Kato

Takashi Hayashi

Satoshi Shimizu

Takahiro Tomoyasu

Takao Taki

Kazuaki Kakehi

Yasuo Koga

Hiroaki Asai

Fumitaka Goto

Kazuhide Ohta

Yoko Sakamoto

Naohiro Hayashi

Minoru Kashimoto

Yukihiko Nosé

Kazunari Izumi

Hiroshi Miyamoto

Masaru Nishida

Wakako Hirano

Atsushi Azuma

Satoru Nakazato

Yukihiko Nose

A low-molecular-weight polysulfated hyaluronic acid derivative useful for treatment of an allergic disease. An agent for treatment of an allergic disease selected from pollinosis, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, and asthma, represented by the following general formula (IA) or (IB); wherein n represents a number of 0 to 15; R's each independently represent a hydrogen atom or an SOH group etc.

Low-molecular polysulfated hyaluronic acid derivative and medicine containing same

The invention provides a way of producing a natural immunologically active state in a person by subjecting him to an apheresis procedure with bioincompatible biomaterials for about one hour. To safely control the immunological shock induced by this procedure, the person is put under general anesthesia for about six hours, including the apheresis time and at least an additional five hours thereafter. This immunological activation is useful for treating malignant tumors and diseases related to immunosuppression, such as AIDS. The invention also provides for the use of an apheresis column containing a blood perfusion filter with bioincompatible materials for treating malignant tumors and infectious diseases.

Immunoactivation blood perfusion filter for the treatment of malignant tumors

Growing community of inventors

Osaka, Japan

Junji Takaba