Ssp Co. Ltd

Ss Pharmaceutical Co., Ltd.

Junji Okawa

Susumu Sato

Shinichi Morimoto

Toshio Yokoyama

Tadayuki Kuraishi

Hiromichi Eto

Haruyoshi Honda

Kinichi Mogi

Naokata Taido

Hiroshi Hasegawa

Noriaki Shioiri

Teruo Komoto

Koichi Tachibana

Yoichiro Ogawa

Kazuo Yamazaki

Noriyuki Kawamoto

Shigeru Adegawa

Tadashi Mikami

Norimitsu Umehara

Hiroyuki Naito

Yoshihisa Sada

Disclosed herein are an imidazole derivative represented by the following general formula (1): ##STR1## wherein R.sup.1 is a hydrogen atom, or an alkyl, alkoxy or alkoxycarbonyl group, and R.sup.2, R.sup.3 and R.sup.4 are the same or different from one another and are independently a hydrogen or halogen atom, an alkyl, halogenoalkyl, hydroxyl or alkoxy group, or the like, or a salt thereof, and a medicine comprising such a compound. The compound specifically suppresses the production of particular cytokine and is hence useful as an active ingredient for immune function modulators and the like.

Imidazole derivative and medicine comprising the same as active

Substituted quinolone derivatives represented by the following formula: ##STR1## wherein R.sup.1 represents a substituted or unsubstituted (hetero)aryl group, R.sup.2 represents H or an alkoxycarbonyl, substituted aminocarbonyl, cyano or like group, and R.sup.3 and R.sup.4 each independently represent H or a substituted alkyl, aryl, amino or like group, and salts thereof; pharmaceuticals containing the same. These derivatives and salts have excellent anti-ulcer activities.

Substituted quinolone derivatives and pharmaceuticals containing the same

Steroid derivatives represented by formula (I) are disclosed. ##STR1## wherein R is a hydrogen atom, a halogen atom, a hydroxy group, or a group --OCOR.sub.1, wherein R.sub.1 is a linear or branched alkyl group which may be substituted by a halogen atom or a cycloalkyl group, a cycloalkyl group, or an aryl group. The compounds are useful for curing or alleviating inflammation or rheumatism.

Antiinflammatory dexamethasone 17.alpha.-cyclopropanecarboxylates with

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Chiba, Japan

Junji Okawa