Terumo Kabushiki Kaisha

Research Development Corporation of Japan

Junji Kimura

Shigeki Suzuki

Masaru Wada

Zensho Kanda

Hideto Ushijima

Kazuo Kawahara

Hideki Uchiyama

Tatsuya Takano

Keiji Nakagami

Ryoichi Hashida

This invention provides a liposome having a drug included therein, which has active targeting property and ensured stability in blood and can be used effectively in the diagnosis and/or treatment of diseases, particularly renal diseases, that accompany production of proteoglycan, comprising (1) a basic compound which takes positive charge within a physiological pH range, (2) a lipid derivative of a hydrophilic polymer and (3) a lipid which constitutes the liposome, as its membrane constituting components, wherein their constituting ratios are from 1 to 20 mol % of (1) based on (3) and from 0.2 to 5 mol % of (2) based on the total of (1) and (3).

Liposomes

Spring biased liquid applicator with integral removable cap

The present invention is concerned with a monoclonal antibody capable of preferentially recognizing arteriosclerotic lesions and prepared from a hybridoma obtained by fusing myeloma cells and cells capable of producing antibodies against arteriosclerotic lesions, such as spleen cells, peripheral lymphocyte of thymus and peripheral vascular cells, the antibody can be to use as an agent for detecting the presence of arteriosclerotic lesions and for treating arteriosclerosis.

Monoclonal antibody capable of recognizing arteriosclerotic lesions and

Medical applicator

Growing community of inventors

Tokyo, Japan

Junji Kimura