Kyowa Hakko Kogyo Co., Ltd.

Junicho Takano

Kuniki Kino

Satoru Furukawa

A temperature-sensitive plasmid which is capable of autonomous replication inK-12 at 10&#x2013;30&#xb0; C., but, at a temperature of 33&#xb0; C. or more, is incapable of autonomous replication inK-12 or is distributed unhomogeneously upon the cell division ofK-12, thereby not to be stably carried within cells ofK-12 under said temperature, and which is incapable of autonomous replication in a microorganism belonging to the genusother thanK-12 or is distributed unhomogeneously upon cell division of said microorganism at any temperature, thereby not to be stably carried within cells of said microorganism.

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Cape Girardeau, MO, United States of America

Junicho Takano