Toyama Chemical Co., Ltd.

Junichi Yokotani

Yoichi Taniguchi

Yukie Tada

Eiji Hara

Hitoshi Akitsu

Hiroshi Kato

Arihiro Takatori

Minori Yanai

Chiharu Tanabe

Hidehiko Tanaka

Shuzo Anzai

The invention relates to an N-acyl anthranilic acid derivative or it's salt having collagen production inhibitory action.

N-acyl anthranilic acid derivative or salt thereof

The anthranilic acid derivative or the salt thereof represented by the general formula wherein Rand Rare hydrogen atom, or the like; Ris a phenyl, cycloalkyl or bicyclic heterocyclic group which may be substituted, or the like; Ris a phenyl, cycloalkyl or pyridyl group which may be substituted, or the like; Xis an alkylene or alkenylene group which may be substituted or a bond; Xis the general formula &#x2014;X&#x2014;X&#x2014; or &#x2014;X&#x2014;X&#x2014;, wherein Xis a sulfur atom, an imino group or a bond, or the like; Xmeans an alkylene or alkenylene group which may be substituted or a bond; is useful for a remedy such as rheumatoid arthritis, osteoarthritis and carcinoma, because it shows MMP&#x2014;13 production inhibitory effect.

Anthranilic acid derivative or salt thereof

An anthranilic acid derivative represented by the general formula (X) [wherein Rrepresents hydrogen or a carboxy-protecting group; Rrepresents optionally substituted phenyl, a heterocyclic group, etc.; Rrepresents optionally substituted phenyl, a monocyclic heterocyclic group, etc.; Xrepresents carbonyl, etc.; Xrepresents optionally substituted alkylene group, a bond, etc.; Xrepresents oxygen, a bond, etc.; and Xrepresents a group represented by the general formula &#x2014;X&#x2014;X&#x2014; or &#x2014;X&#x2014;X&#x2014; (wherein Xmeans oxygen, a bond, etc.; and Xmeans optionally substituted alkylene, a bond, etc.)] or a salt of the derivative. The derivative or salt has the inhibitory activity of MMP-13 production and is hence useful as a therapeutic agent for articular rheumatism, osteoarthritis, cancer, etc.

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Toyama, Japan

Junichi Yokotani