Nippon Shinyaku Company, Ltd.

Yano, Junichi

Ohgi, Tadaaki

Junichi Yano

Tadaaki Ohgi

Kazuko Hirabayashi

Koichi Ishiyama

Antiviral c-nucleoside derivatives

Cyclic AMP and cyclic GMP derivatives, such as 8-bromoadenosine-3', 5'-cyclic methylphosphonate, are effective in inhibiting phosphodiesterases.

Adenosine and guanosine-3'-5'-cyclic methylphosphonate derivatives

Nucleic acid derivatives and pharmaceutical compositions containing such derivatives are produced containing one 4-thiouridylic acid for every 6 to 39 cytidylic acids present, which has a length of from 50 to 10,000 base pairs. Methods of treatment using these nucleic acid derivatives to treat viral infections is also described.

Size limited double stranded poly I poly(cytidylate/4-thiouridylate)

Growing community of inventors

Nara, Japan

Junichi Yano