Snow Brand Milk Products Co., Ltd.

Fujino Patent Attorney

Junichi Yamamura

Yukihiro Takada

Seiichiro Aoe

Masaaki Goto

Ken Kato

Hiroaki Matsuyama

Yasuhiro Toba

The present invention is to provide a novel medicine, drink, food or feed having an action of strengthening bone. More specifically, the present invention is to provide a medicine, drink, food or feed combined with collagen, fraction containing collagen or degradation product thereof. Fraction containing collagen was prepared by mincing skin corium layer into pieces, defatting it and lyophylization or by pulverizing bone, decalcifying it and lyophylization. Oral administration of these can stimulate proliferation of osteoblast, inhibit bone resorption and strengthen bone. They can be useful for improvement of osteoporosis, bone fracture, bone pain, etc.

Medicine drink food and feed having an action of strengthening bone

The present invention provides a basic protein and a basic peptide composition which can be administered orally and has the ability to stimulate osteoblast proliferation, strengthen bone and inhibit bone resorption. Said basic protein has the following properties: (1) a molecular weight distribution of is 2,000-24,000; (2) an isoelectric point distribution of is 7.5-11; and (3) it is comprised of more than 10% of basic amino acids. Said composition can be obtained by the following steps: After milk, or raw material derived from milk, is loaded onto a cation exchange resin column, a fraction is obtained by eluting with an eluent of 0.1-1.0M salt concentration, precipitate removed by (i) heating to over 75.degree. C., (ii) by adding alcohol so that the final concentration thereof is 10-50% or (iii) by adding salts so that the final concentration thereof will be more than 0.2M; and the supernatant thereof containing the basic protein fraction recovered.

Basic protein composition, basic peptide composition and application

The present invention will provide an agent promoting bone formation and inhibiting bone resorption comprising kininogen and degradation product of kininogen as an effective ingredient. Fragment 1.multidot.2 is a preferable degradation product of kininogen. Further, the present invention will provide a drink, food, medicine and feed combined with kininogen and degradation product of kininogen.

Kininogen agent promoting bone formation and inhibiting bone resorption

A method for promoting osteoblast proliferation or inhibiting bone resorption comprising administering to a subject in need thereof, a composition comprising High Mobility Group Protein (HMG-1) is disclosed.

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Kawagoe, Japan

Junichi Yamamura