Sumitomo Chemical Company, Limited

Junichi Tomokawa

Norihiko Hirata

Kazuhiro Yamauchi

Takahiro Kimura

The present invention provides an industrially advantageous production method of (1R,2S)-2-{[((2,4-dimethylpyrimidin-5-yl)oxy}methyl]-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropane-1-carboxamide. (1R,2S)-2-{[((2,4-Dimethylpyrimidin-5-yl)oxy}methyl]-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropane-1-carboxamide (compound [A]) is produced by an industrially advantageous method by a route via a novel compound. wherein each symbol is as described in the description.

Method for manufacturing cyclopropane compound

A carboxamide can be produced in a high yield by a method for producing a carboxamide, for example, represented by formula (4): (wherein Rand Rare as defined below), the method comprising a step of allowing a carboxylic acid ester represented by formula (1): (wherein Rrepresents an optionally substituented C-Chydrocarbon group or an optionally substituented C-Cheterocyclic group, and Rrepresents an optionally substituented C-Chydrocarbon group), an amine represented by formula (2):R&#x2014;NH&#x2003;&#x2003;(2)(wherein Rrepresents a hydrogen atom or an optionally substituented C-Chydrocarbon group), and a formamide compound represented by formula (3): (wherein Ris as defined above) to react in the presence of a metal alkoxide.

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Itami, Japan

Junichi Tomokawa