Tanabe Seiyaku Company, Limited

Tanabe Seikaku Co., Ltd.

Junichi Tani

Yoshihisa Yamada

Totaro Yamaguchi

Toyonari Oine

Ryuichi Ishida

Satoshi Ohshima

Ichizo Inoue

Takashi Ochiai

Yoshitaka Mushika

A quinoline compound of the formula: ##STR1## wherein R.sup.1 is hydrogen or fluorine. A method of preparing the compound (I) is disclosed. The compound (I) and a pharmaceutically acceptable salt thereof are useful as antimicrobial agents.

Quinoline compound useful as antibacterial agents in warm-blooded animals

N-(2-amino-5-nitrobenzoyl)-o-toluidine is condensed with fluoroacetic acid or a functional derivative thereof. N-(2-fluoroacetamido-5-nitrobenzoyl)-o-toluidine obtained by said condensation reaction is dehydrated to produce 2-fluoromethyl-3-(o-tolyl)-6-nitro-4(3H)-quniazolinone, which is then subjected to reduction reaction. 2-fluoromethyl-3-(o-tolyl)-6-amino-4(3H)-quinazolinone thus obtained and a pharmaceutically acceptable acid addition salt thereof are useful as central muscle relaxants, minor tranquilizers, anti-convulsants, analgesics and/or anti-inflammatory agents.

2-Fluoromethyl-3-o-tolyl-6-amino-4(3H)-quinazolinone

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Osaka, Japan

Junichi Tani