Sumitomo Seika Chemicals Co., Ltd.

Junichi Sakamoto

Hiroshi Goda

Shigeki Sakaue

Sakae Kajihara

Miki Todo

Hideaki Nishiguchi

There is disclosed a process for preparing 3-piperazinylbenzisothiazoles comprising reacting the specified 3-halo-1,2-benzisothiazole or 2-cyanobenzenesulfenyl halide in the presence of an alkylene glycol derivative. The process is industrially effective, easy and economical and can provide useful intermediates for production of pharmaceutical preparations.

Process for preparation of 3-piperazinylbenzisothiazoles

Process for preparation of 3 piperazinylbenzisothiazoles

The present invention provides processes for preparing .alpha.-halo(methylthio)acetophenone and .alpha.-halo (methylsulfonyl)acetophenone in an industrially simple and economically advantageous manner. In the invention, methylthioacetophenone is halogenated with a halogenating agent in the presence of an alcohol, giving .alpha.-halo(methylthio) acetophenone. Then the compound is oxidized with an oxidizing agent, giving .alpha.-halo(methylsulfonyl)acetophenone.

Process for preparing .alpha.-haloacetophenone derivative

The present invention provides a compound represented by the general formula (I): ##STR1## wherein X represents Cl or Br, a process for preparation of the same and a process for preparation of 3-substituted benzisothiazole by reaction of the compound (I) with a piperazine compound.

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Hyogo-ken, Japan

Junichi Sakamoto