Sharp Corporation

Panasonic Intellectual Property Management Co., Ltd.

Takeda Chemical Industries, Inc.

Sharp Kabushiki Kaisha Corporation

Matsushita Electric Industrial Co., Ltd.

Takeda Pharmaceutical Company Limited

Junichi Sakamoto

Akira Kano

Hiroyuki Kimura

Hiroyuki Odaka

Yu Momose

Kensuke Nakura

Nobuhiko Hojo

Tooru Matsui

Hiroshi Nishibori

Kazuko Asano

Hiroshi Imoto

Yoshihisa Ohie

Ryohei Miyamae

Kiyohiro Isii

Harumi Tatsugami

Yuji Tani

Hiromiti Yamada

Katsumi Jinbo

Kiyoshi Kanamura

Shigekazu Sasaki

Hirotetsu Suzuki

Yasuo Sugiyama

Shigetoshi Hazama

Shinichi Yokoyama

Hidekazu Sawada

Masashi Omura

Hiromichi Yamada

Kohji Fukatsu

Kouji Satake

Hidehito Uemura

Yuichiro Amano

Kazumasa Hamamura

Isao Kitae

A non-aqueous electrolyte secondary battery, wherein a negative electrode includes a negative electrode mixture layer having a thickness T and a negative electrode current collector, the negative electrode active material includes carbon and Si-containing materials, wherein when the negative electrode mixture layer is divided into a first region having a thickness of T/2 on the surface side of the negative electrode and a second region having a thickness of T/2 on the negative electrode collector side, a mass ratio of the first to the second composite material contained in the first region is >1, a mass ratio of the first composite to the second composite material contained in the second region is <1, and, in a fully charged condition, an open circuit potential of the negative electrode is 0 V or more and 70 mV or less with respect to a lithium metal.

Nonaqueous electrolyte secondary battery

A non-aqueous electrolyte secondary battery with a negative electrode active material including a carbon material, and a silicon-containing material in which Si particles are dispersed in a lithium ion conductive phase. The negative electrode material mixture layer having a thickness Tincludes a first region on the negative electrode surface side having a thickness of T, and a second region on the negative electrode current collector side, and the ratio T/Tis 1/20 to 19/20. The ratio of a mass ratio Mof the silicon-containing material in the first region to a mass ratio Mof the silicon-containing material in the second region is not less than 0 and less than 1. An open circuit potential of the negative electrode in a fully charged condition is higher than 0 mV and 70 mV or lower relative to lithium metal.

Non-aqueous electrolyte secondary battery

A lithium secondary battery according to the present disclosure comprises a cathode, an anode; and a non-aqueous electrolyte having lithium ion conductivity. A lithium metal is precipitated on a surface of the anode during charge of the lithium secondary battery. The lithium metal is dissolved from the surface of the anode in the non-aqueous electrolyte during discharge of the lithium secondary battery. The non-aqueous electrolyte contains a solvent and a lithium salt. The lithium salt includes a first lithium salt and a second lithium salt. The second lithium salt is different from the first lithium salt. The first lithium salt is composed of a lithium ion and an ate complex anion. A sum of concentration of the first lithium salt and the second lithium salt which are contained in the non-aqueous electrolyte is not less than 3.0 mol/L.

Lithium secondary battery

A lithium secondary battery includes: a positive electrode; a negative electrode; a separator disposed between the positive electrode and the negative electrode; and a nonaqueous electrolyte solution filled between the positive electrode and the negative electrode. The negative electrode includes: an electrically conductive layer having a surface; and lithium metal pieces arranged spaced from each other on the surface of the electrically conductive layer. There is no lithium metal on an imaginary line extending from a first end to a second end opposite to the first end of the surface of the electrically conductive layer and traversing a space between the lithium metal pieces.

Lithium secondary battery including lithium metal as negative electrode active material

A lithium secondary battery includes: a positive electrode; a negative electrode including a negative electrode collector having a surface, on which a lithium metal is deposited during charge; a separator disposed between the positive electrode and the negative electrode; and a nonaqueous electrolyte solution filled between the positive electrode and the negative electrode. The negative electrode collector includes projection portions projecting from the surface toward the separator. There is no projection portion on an imaginary line extending from a first end to a second end opposite to the first end of the surface of the negative electrode collector and traversing a space between the projection portions.

A lithium secondary battery includes a wound electrode group and a lithium-ion conductive nonaqueous electrolyte. The wound electrode group includes a positive electrode, a negative electrode, and a separator between the positive electrode and the negative electrode. The negative electrode includes a negative electrode current collector. The negative electrode current collector includes: a layer having a first surface facing outward of the winding of the electrode group and a second surface facing inward of the winding of the electrode group; first protrusions protruding from the first surface; and second protrusions protruding from the second surface. Lithium metal is deposited on the first surface and the second surface by charging. A second average height of the second protrusions is higher than a first average height of the first protrusions.

Lithium secondary battery including lithium-ion conductive nonaqueous electrolyte

A lithium metal secondary battery includes a positive electrode, a negative electrode, a solid electrolyte, and a soft electrolyte. The negative electrode includes a negative electrode current collector having at least one hole, in which lithium metal is deposited in a charged state. The solid electrolyte is disposed on the surface, which face negative electrode current collector, of the positive electrode. The soft electrolyte fills the space between the negative electrode current collector and solid electrolyte and entering into the at least one hole. The solid and soft electrolytes have lithium ion conductivity.

Lithium metal secondary battery using lithium metal as negative electrode active material

A lithium secondary battery includes a wound electrode group and a lithium-ion conductive nonaqueous electrolyte. The wound electrode group includes a positive electrode, a negative electrode, and a separator between the positive electrode and the negative electrode. The negative electrode includes a negative electrode current collector. The negative electrode current collector includes: a layer having a first surface facing outward of the winding of the electrode group and a second surface facing inward of the winding of the electrode group; first protrusions protruding from the first surface; and second protrusions protruding from the second surface. Lithium metal is deposited on the first surface and the second surface by charging. A first average height of the first protrusions is higher than a second average height of the second protrusions.

An electrochemical device includes a negative electrode containing a negative electrode active material, a positive electrode, and an electrolyte. The negative electrode active material has a crystal structure with an Fm3m space group and contains a compound represented by composition formula (1) below,LiTiO&#x2003;&#x2003;Formula (1),

Electrochemical device with negative electrode active material having an Fm3m space group

A lithium secondary battery includes a positive electrode, a negative electrode on which a lithium metal is deposited in a charged state, a separator disposed between the positive electrode and the negative electrode, and a nonaqueous electrolyte containing a nonaqueous solvent and a lithium salt containing a carborane anion.

Lithium secondary battery including electrolyte containing carborane anion

The present invention provides a compound represented by the formula (I): [wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, p is 0, 1 or 2, and when p is 2, each R may be the same or different, Ris a hydrogen atom or an optionally substituted hydrocarbon group, Ris an optionally substituted aromatic group, Ring A is an optionally substituted monocyclic aromatic ring or optionally substituted bicyclic aromatic fused ring, Xis an oxygen atom or a sulfur atom, Xis a bond, an oxygen atom or &#x2014;S(O)&#x2014; (wherein n is 0, 1 or 2), Y is a bond, an oxygen atom, &#x2014;S(O)&#x2014;, &#x2014;C(&#x2550;O)&#x2014;N(R)&#x2014; or &#x2014;N(R)&#x2014;C(&#x2550;O)&#x2014; (Ris a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, and m is 0, 1 or 2), M, Mand Mmay be the same or different and are each independently a bond or an optionally substituted divalent aliphatic hydrocarbon group, and Mis an optionally substituted divalent aliphatic hydrocarbon group] or a salt thereof, which is useful as a prophylactic and/or therapeutic agent for lipid metabolism abnormality, arteriosclerotic disease and sequelae thereof, diabetes mellitus and the like.

Furan or thiophene derivative and medicinal use thereof

To provide a novel oxyiminoalkanoic acid derivative which has excellent hypoglycemic and hypolipidemic actions and which is used for the prevention or treatment of diabetes mellitus, hyperlipemia, insulin insensitivity, insulin resistance and impaired glucose tolerance. A compound represented by the formula: wherein Ris an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X is a bond, &#x2014;CO&#x2014;, &#x2014;CH(OH)&#x2014; or a group represented by &#x2014;NR&#x2014; wherein Ris a hydrogen atom or an optionally substituted alkyl group; n is an integer of 1 to 3; Y is an oxygen atom, a sulfur atom, &#x2014;SO&#x2014;, &#x2014;SO&#x2014; or a group represented by &#x2014;NR&#x2014; wherein Ris a hydrogen atom or an optionally alkyl group; ring A is a benzene ring optionally having additional one to three substituents; p is an integer of 1 to 8; Ris a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; q is an integer of 0 to 6; m is 0 or 1; Ris a hydroxy group, OR(Ris an optionally substituted hydrocarbon group.) or NRR(Rand Rare the same or different groups which are selected from a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group or an optionally substituted acyl group or Rand Rcombine together to form a ring); Rand Rare the same or different groups which are selected from a hydrogen atom or an optionally substituted hydrocarbon group wherein Rmay form a ring with R; provided that when Ris a ethoxymethyl, a Calkyl, phenyl or p-methoxyphenyl and q=m=0, Ris NRR; and provided that O-[2-chloro-4-(2-quinolylmethoxy)phenylmethyl]oxime and a methyl pyruvate of [2-chloro-4-(2-quinolylmethoxy)phenylmethyl]-2-iminoxypropionic acid are excluded; or a salt thereof.

Oxyiminoalkanoic acid derivatives

The present invention provides a novel protein and its use. The protein or its salt, the partial protein, its amide or ester, or salts, and DNA encoding the same can be employed for obtaining antibodies and antisera, constructing the expression system of the protein of the present invention, for constructing the assay system for the GABA transporter activity and screen medicament candidate compounds using the expression system, for making drug design based on the steric structure of GABA transporters, as agents for producing probes or PCR primers in gene diagnosis, for preparing transgenic animals or as pharmaceuticals for the prevention/treatment of genetic disorders.

GABA transporter protein and DNA thereof

1,3-Azole derivatives, pharmaceutical compositions thereof and methods for regulating the function of retinoid-related receptors with 1,3-azole derivatives are disclosed. Such regulation may be useful for preventing or treating diabetes, preventing or treating hyperlipidemia, preventing or treating impaired glucose tolerance (IGT) or for preventing transition from impaired glucose tolerance to diabetes.

Growing community of inventors

Osaka, Japan

Junichi Sakamoto