Otsuka Pharmaceutical Company, Limited

Otsuka Pharmaceutical Factory, Inc.

Junichi Minamikawa

Michiaki Tominaga

Takao Nishi

Muneaki Kurimura

Shinji Aki

Akihiro Yamamoto

Norihiro Fukuyama

Kinji Hashimoto

Makoto Inoue

Shinji Nishitani

Yoshiaki Manabe

Junichiro Otsubo

Masanobu Kano

The present invention provides a process for producing carbostyril derivatives (I) which are known to be useful as medical drug such as antithrombotic agent, cerebral circulation improver, anti-inflammatory agent, antiulcer agent, etc. in a high yield and a high purity. The carbostyril derivatives (I) can be produced by reacting a carbostyril derivative (II) with a tetrazole derivative (III) in the presence of a phase transfer catalyst. 

Process for producing carbostyril derivatives

The present invention provides a process for producing carbostyril derivatives (I) which are known to be useful as medical drug such as antithrombotic agent, cerebral circulation improver, anti-inflammatory agent, antiulcer agent, etc. in a high yield and a high purity. The carbostyril derivatives (I) can be produced by reacting a carbostyril derivative (II) with a tetrazole derivative (III) in the presence of a phase transfer catalyst.

3-halogeno-2,3-diphenylacrylaldehyde derivatives, process for preparing

Process for preparing dihydropyridine derivatives and salts and esters thereof represented by the general formula ##STR1## from a phenyl derivative and an enamine derivative in which the phenyl derivative is prepared by reacting a compound of the formula ##STR2## with a compound of the formula ##STR3## in the presence of an aromatic amine selected from o-, m-, p- anisidine; m-, p-toluidine; p-chloroaniline; aniline and o-phenetidine.

Process for preparing novel dihydropyridine derivatives

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Naruto, Japan

Junichi Minamikawa