Kao Corporation

Kanebo Cosmetics Inc.

Junichi Matsui

Masaki Yoshida

Takeshi Ikemoto

Akinori Haratake

Shunsuke Yamazaki

Hideyo Uchiwa

Sachiyo Hirotsu

Motoi Hayase

The present invention provides a method for enhancing epidermal permeability barrier function of the aged skin, which includes the step of externally administering to the aged skin an amount of a fumaric acid diester derivative expressed by the following general formula (1) as an active ingredient wherein Rrepresents a Calkylene group; Rand Reach represents a linear or branched Calkyl group; and n is an integer of 2 to 5.

Skin external agents and drugs

Skin external agent compositions and drugs characterized by containing fumaric acid diester derivatives represented by following general formula (1), wherein Rrepresents Calkylene; Rand Rrepresent each liner or branched Calkyl; and n is an integer of 2 to 5; which provide epidermal barrier function potentiating agents and skin external agent compositions having a high safety, quickly relieving epidermal permeation barrier function failures and having an effect of maintaining the skin in a cosmetologically healthy state; agents to be used together with HB-EFG expression inducing agents accelerating epidermal turnover, amphiregulin expression inhibitors regulating excessive epidermal proliferation, and retinoic acid or its derivative preventing skin chapping caused by retinoic acid or its derivative; and skin aging relieving agents capable of ameliorating depression in the skin metabolism and thinning in association with aging.

Growing community of inventors

Odawara, Japan

Junichi Matsui