Jcr Pharmaceuticals Co., Ltd.

Noda Shokukin Kogyo Co., Ltd.

Junichi Koga

Hajime Hiratani

Yasuhiro Ohashi

Hiroyuki Shirono

Akio Matsuo

LEM which is an aqueous extract of a mycelial culture of Lentinus Edodes and has a sugar composition composed of arabinose, xylose, glucose, mannose, galasctose, fucose and rhamnose, as well as a fraction of LEM which corresponds to molecular weights of 10,000 to 1,000,000 daltons and has a sugar composition composed of arabinose, xylose, glucose, mannose and galactose are provided as agents for inhibiting the adsorption of herpesviruses such as herpes simplex to the cells.

Inhibitor of herpesvirus absorption

An inhibitor of the proliferation of herpesviruses and of the recurrence of affections caused by their latent infection, which is an active material obtained by fractional purification of the aqueous extract from cultured Lentinus edodes mycelia.

Inhibitor of the proliferation of herpes viruses and inhibitor of the

Antiserum which can recognize all subtypes of human leukocyte interferon is prepared from the blood of an animal immunized with partially purified human leukocyte interferon obtained from a culture of human leukocyte stimulated with Sendai virus. The antiserum is added to a column whereon concentrated culture broth of human leukocyte has been immobilized to adsorb impurities, the effluent is added to a column whereon partially purified human leukocyte interferon has been immobilized to adsorb anti-human leukocyte interferon antibody and then the antibody is eluted from the column. The antibody thus obtained recognizes all subtypes of human leukocyte interferon and can be separated by a chromatography to each monoclonal antibody which recognizes a single subtype. Employing these antibodies, the subtypes of human leukocyte interferon or their antibodies in a sample can be analized or assayed.

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Kobe, Japan

Junichi Koga