Kissei Pharmaceutical Co., Ltd.

Junichi Kobayashi

Tetsuro Tamai

Satoshi Akahane

Takehiro Ishikawa

Nobuyuki Tanaka

Hiromu Harada

Harunobu Mukaiyama

Hideyuki Muranaka

Tetsuya Nakamura

Yuichiro Kai

Tatsuhiro Kondo

Tomonaga Ozawa

Ritsu Suzuki

Hideaki Hirasawa

Nobuhiko Fushimi

Naohiro Kawamura

Yoshiro Kijima

Yousuke Mutai

Fumiya Tanada

The present invention is to provide a novel pyrazole derivative, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same, and a pharmaceutical use thereof. The present invention provides a compound represented by the formula (I) or a pharmaceutically acceptable salt thereof, which has TRPM8 inhibitory effects: wherein ring A is Caryl or the like; X is CRor the like; Rand Rare a hydrogen atom or the like; Ris a hydrogen atom or the like; Ris a hydrogen atom or the like; ring B is Caryl or the like; Ris a hydrogen atom or the like; Ris a hydrogen atom or the like; Ris a hydrogen atom or the like; Ris a hydrogen atom or the like; Ris a hydrogen atom or the like; Ris a hydrogen atom or the like; n is 0, 1 or 2. Therefore, the compound represented by the formula (I) of the present invention or a pharmaceutically acceptable salt thereof is useful as an agent for treating or preventing diseases or symptoms caused by hyperexcitability or disorder of afferent neurons.

Pyrazole derivative or pharmaceutically acceptable salt thereof

The present invention is to provide a novel &#x3b1;-substituted glycinamide derivative, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same, and a pharmaceutical use thereof. The present invention provides a compound represented by the general formula (I), which has TRPM8 inhibitory effects: [wherein Arepresents a Caryl and the like, Arepresents a Caryl and the like, X represents CH and the like, Y represents &#x2014;CRR&#x2014; and the like, Rand Rindependently represent a hydrogen atom and the like, Rand Rindependently represent a halogen atom and the like, n is 1 or 2], or a pharmaceutically acceptable salt thereof. Furthermore, the compound (I) of the present invention can be used as an agent for treating or preventing diseases or symptoms caused by hyperexcitability or disorder of afferent neurons.

&#x3b1;-Substituted glycinamide derivative

The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein Rand Rare each hydrogen or lower alkyl; R, R, Rand Rare each hydrogen, halogen, lower alkyl or lower alkoxy; Rand Rare each hydrogen, halogen, lower alkyl, halo-lower alkyl, lower alkoxy, cycloalkyl, aryl, heteroaryl, cyano, a hydroxyl group, lower acyl, carboxy or the like; Ris &#x2014;C(O)&#x2014;R, -A-C(O)&#x2014;R, &#x2014;O-A-C(O)&#x2014;Ror a tetrazol-5-yl group, which exhibit potent and selective &#x3b2;3-adrenoceptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

Amino alcohol derivatives, pharmaceutical compositions containing the same, and use thereof

The present invention provides compounds represented by general formula (I): a prodrug thereof, or pharmaceutical acceptable salts thereof, wherein Ris hydrogen or lower alkyl; each of R2 and R3 is independently hydrogen or lower alkyl; each of R, Rand Ris independently hydrogen, halogen, lower alkyl or lower alkoxy; Ris hydrogen or lower alkyl; Ris hydrogen, halogen, lower alkyl, lower alkoxy, etc; Ris &#x2014;COR, -A-COR, &#x2014;O-A-COR, etc; Ar is optionally substituted phenyl or heteroaryl; and A is a bond, &#x2014;OCH&#x2014;, etc, which exhibit potent and selective &#x3b2;3-adrenoceptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

Amino alcohol derivatives, medicinal composition containing the same, and use of these

The present invention provides novel intermediates represented by general formula (I) etc. for preparing a phenoxyacetic acid derivative represented by general formula (X) or a pharmaceutically acceptable salt thereof, which has &#x3b2;3-adrenoceptor stimulating activity and are useful for treating or preventing obesity, hyperglycemia, diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression or biliary calculus. The present invention also provides a process for preparing said intermediates and a method of using said intermediates 

Intermediates in producing phenoxyacetic acid derivatives and method of using the same

Intermediates in producing phenoxyacetic acid preventives and method of using the same

The present invention provides novel intermediates represented by general formula (I) etc. for preparing a phenoxyacetic acid derivative represented by general formula (X) or a pharmaceutically acceptable salt thereof, which has &#x3b2;3-adrenoceptor stimulating activity and are useful for treating or preventing obesity, hyperglycemia, diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression or biliary calculus. The present invention also provides a process for preparing said intermediates and a method of using said intermediates. 

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Hotaka-machi, Japan

Junichi Kobayashi