Kowa Company Limited

The University of Edinburgh

University of Strathclyde

Junichi Kawagoe

Takashi Nakagawa

Toru Kanke

Yoichi Yamauchi

Toshiaki Takizawa

Hiroyuki Ishiwata

Yasushi Wada

Mototsugu Kabeya

Alan Lang Harvey

Yasushi Abiko

Hiroko Hashizume

Louise Claire Young

Akiyoshi Hara

Robert Ramage

Pu Wang

Lu Jiang

Koji Abe

Robin Plevin

Kevin Thomas Shaw

The present invention is intended to clarify the relationship between PAR-2 and cerebral infarction and thereby provide an efficient method of preventing and treating cerebral infarction, as well as a pharmaceutical composition therefore. Namely, the present invention relates to a method of preventing and treating cerebral infarction by activating PAR-2 and/or promoting expression of PAR-2 gene. The present invention further relates to a pharmaceutical composition for preventing and treating cerebral infarction, comprising one, or two or more of the active ingredients selected from the group consisting of a PAR-2 activator and/or a PAR-2 gene expression promoter; as well as a pharmaceutically acceptable carrier. It further relates to a method of screening an active ingredient for preventing and treating cerebral infarction using as an indicator the PAR-2 activation promoted by a test substance.

Method of preventing and treating brain infarction

The present invention relates to a peptide derivative represented by the general formula (I) or a salt thereof: Z-(CH)&#x2014;CO&#x2014;NH-Leu-Ile-Gly-AA-AA-CO&#x2014;R (I) wherein Z represents an aryl group which may or may not have a substituent or a heteroaryl group which may or may not have a substituent; n represents 0, 1 or 2: AA-AArepresents Lys-Val or Arg-Leu; and R represents &#x2014;OH or &#x2014;NH, and relates to a pharmaceutical composition comprising a peptide derivative represented by the general formula (I) or a salt thereof, and a pharmaceutically acceptable carrier thereof. The peptide derivative is useful as a prophylactic and therapeutic agent of dysfunction of masticatory, dysphagia, dysgeusia, ozostomia, intra-oral cavity dysphoria, intra-oral cavity infections, intra-oral cavity inflammations, dry eye, ectocornea detachment, keratitis, corneal ulcer, conjunctivitis, stomach ulcer, duodenal ulcer, gastritis, diarrhea, enteritis or Sjogren's syndrome.

Par-2-activating peptide derivative and pharmaceutical composition using the same

The present invention relates to a composition for prevention and treatment of kidney diseases comprising one or more effective component(s) of a PAR-2 activating agent which is able to activate PAR-2 and a pharmaceutically acceptable carrier. The present invention further relates to a method for prevention and treatment of kidney diseases comprising administration of a composition for prevention and treatment of kidney diseases containing a PAR-2 activating agent which is able to activate PAR-2 to patients suffering from kidney diseases, and also relates to the use of a PAR-2 activating agent which is able to activate PAR-2 for the manufacture of a composition for prevention and treatment of kidney diseases. The present invention furthermore relates to a method for screening an effective ingredient for prevention and treatment of kidney diseases comprising screening of the activating action of the test substance to PAR-2.

Method for treatment of kidney diseases

Preventive and therapeutic agent for kidney diseases

A therapeutic agent for myocardial ischemic damages or reperfusion injuries which contains, as an active ingredient, a compound of the following formula (1), an acid addition salt thereof, or a hydrate thereof: ##STR1## wherein R.sup.1 to R.sup.6 are lower alkoxy groups and A and A' are lower alkylene groups; a method for treating those disorders which uses the above compound; and use of the compound in the manufacture of such a therapeutic agent. The therapeutic agent has an excellent action of recovering lowered heart functions caused by myocardial ischemia-reflow, and have low toxicity.

Therapeutic agent for myocardial ischemic damages or reperfusion

Growing community of inventors

Saitama, Japan

Junichi Kawagoe