Toray Industries, Inc.

Shiga University of Medical Science

Junichi Kasuya

Yoshiyuki Ueno

Ryo Matsunaga

Yuji Ueda

Masato Masuda

Kazuo Teramoto

Joji Funakoshi

Naotoshi Tomita

Yasunori Kanemori

Kazumasa Ogasawara

Hirofumi Yamanaka

An objective of the present disclosure is to provide an adsorption material that has a carrier material with retained physical strength, and efficiently adsorbs an immunosuppressive protein. The present disclosure provides an adsorption material for immunosuppressive protein. The adsorption material includes a water-insoluble carrier to which at least one nitrogen-containing compound selected from a polyamine represented by a predetermined formula and aliphatic amines represented by predetermined formulae is bound. A total content of amino groups on the water-insoluble carrier is more than 0 &#x3bc;mol and 2500 &#x3bc;mol or less per 1 g, and a content of primary amino groups on the water-insoluble carrier is 450 &#x3bc;mol or less per 1 g.

Immunosuppressive protein adsorption material and adsorption column

An object of the present invention is to provide a ligand-immobilized sea-island composite fiber in which generation of fine particles due to peeling of a sea component from an island component and generation of fine particles due to destruction of a fragile sea component are both suppressed. The present invention provides a sea-island composite fiber comprising a sea component and island components, in which a value (L/S) obtained by dividing the average total length (L) of the perimeter of all island components in a cross section perpendicular to the fiber axis by the average cross-sectional area (S) of the cross section is from 1.0 to 50.0 &#x3bc;m, a distance from the surface to the outermost island component is 1.9 &#x3bc;m or less, and an amino group-containing compound is covalently bonded to a polymer constituting the sea component at a charge density of 0.1 &#x3bc;mol or more and less than 500 &#x3bc;mol per 1 gram dry weight.

Sea-island composite fiber, carrier for adsorption, and medical column provided with carrier for adsorption

A fiber for protein adsorption has a water absorption percentage of 1 to 50%, and the fiber includes a polymer containing as repeat units an aromatic hydrocarbon or a derivative thereof, wherein part of aromatic rings contained in the repeat units are cross-linked through a structure represented by Formula (I). A column for protein adsorption uses the fibers. A in Formula (I) is selected from an alkyl aliphatic group, phenyl aromatic group and amino group. 

Fiber and column for protein adsorption

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Otsu, Japan

Junichi Kasuya