Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Junichi Kamata

Akihiko Tsuruoka

Keiko Takahashi

Yasuhiro Funahashi

Toru Haneda

Yuji Yamamoto

Norihiro Ueda

Masayuki Matsukura

Kazuki Miyazaki

Tadashi Okabe

Kazumasa Nara

Takashi Owa

Taro Semba

Shinichi Hamaoka

Toshiaki Wakabayashi

Naoko Hata

Tomohiro Matsushima

Yoshio Fukuda

Yoichi Ozawa

Tatsuo Watanabe

Hiroshi Obaishi

Junji Matsui

Noako Tsukahara

Ichiro Yoshida

Atsumi Yamaguchi

Katsuji Nakamura

Fusayo Mimura

Sachi Suzuki

Ken-ichi Nomoto

Yasuyuki Suzuki

Toshihiko Kaneko

Yoshinori Takahashi

Fumihiro Ozaki

Mitsuaki Miyamoto

Naoki Yoneda

Hiroki Ishihara

Kohei Sawada

Yasutaka Takase

Hiromitsu Yokohama

Yoshiaki Ohashi

Hiroshi Katoh

Takashi Yoshinaga

Shuichi Suzuki

Yoshinori Sakuma

Kiyoaki Kobayashi

Itaru Arimoto

Manabu Shirato

Mutsuko Tabata

Tatsuhiro Onogi

Naoko Tsukahara

Hidenori Seshimo

Hiroyuki Suzuki

Takako Yoshiba

Daiya Shimokubo

Miyuki Ohkubo

Futoshi Miyazaki

Kenji Matsui

Ken-Ichi Nomoto

Compounds represented by the following general formula: [wherein Ais an optionally substituted 5- to 14-membered heterocyclic group, etc.; Xis &#x2014;O&#x2014;, &#x2014;S&#x2014;, etc.; Yis an optionally substituted Caryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and Tis a group represented by the following general formula: (wherein Eis a single bond or &#x2014;N(R)&#x2014;, Rand Reach independently represent a hydrogen atom, an optionally substituted Calkyl group, etc. and Zrepresents a Calkyl group, a Calicyclic hydrocarbon group, a Caryl group, etc.)],salts thereof or hydrates of the foregoing.

Nitrogen-containing aromatic derivatives

The present invention provides an integrin expression inhibitor, and an agent for treating arterial sclerosis, psoriasis, cancer, retinal angiogenesis, diabetic retinopathy or inflammatory diseases, an anticoagulant, or a cancer metastasis suppressor on the basis of an integrin inhibitory action. Namely, it provides an integrin expression inhibitor comprising, as an active ingredient, a sulfonamide compound represented by the following formula (I), a pharmacologically acceptable salt thereof or a hydrate of them, wherein in the formula, B means a C6-C10 aryl ring or 6- to 10-membered heteroaryl ring which may have a substituent and in which a part of the ring may be saturated; K means a single bond, &#x2014;CH&#x2550;CH&#x2014; or &#x2014;(CRR)&#x2014; (wherein Rand Rare the same as or different from each other and each means hydrogen atom or a C1-C4 alkyl group; and mmeans an integer of 1 or 2); Rmeans hydrogen atom or a C1-C6 alkyl group; Z means a single bond or &#x2014;CO&#x2014;NH&#x2014;; and R means a C6-C10 aryl ring or 6- to 10-membered heteroaryl ring which may have a substituent and in which a part of the ring may be saturated, respectively.

Integrin expression inhibitor

Compounds represented by the following general formula: [wherein Ais an optionally substituted 5- to 14-membered heterocyclic group, etc.; Xis &#x2014;O&#x2014;, &#x2014;S&#x2014;, etc.; Yis an optionally substituted Caryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and Tis a group represented by the following general formula: (wherein Eis a single bond or &#x2014;N(R)&#x2014;, Rand Reach independently represent a hydrogen atom, an optionally substituted Calkyl group, etc. and Zrepresents a Calkyl group, a Calicyclic hydrocarbon group, a Caryl group, etc.)], salts thereof or hydrates of the foregoing.

A compound represented by the general formula: wherein Xrepresents a nitrogen atom or a group represented by the formula &#x2014;CR&#x2550;; Xrepresents a nitrogen atom or a group represented by the formula &#x2014;CR&#x2550;; Y represents an oxygen atom or the like; Rrepresents a Calkoxy group, an optionally substituted Caryloxy group, a group represented by the formula &#x2014;NRRor the like; Rrepresents a hydrogen atom, an optionally substituted Calkyl group, or the like; R, R, R, R, R, R, Rand Reach independently represent a hydrogen atom, a halogen atom, an optionally substituted Calkyl group, or the like; Rrepresents a group represented by the formula &#x2014;NRRor the like; and R, R, Rand Reach independently represent a hydrogen atom, an optionally substituted Calkyl group, or the like,a salt thereof, or a hydrate of the foregoing.

Compounds represented by the following general formula: [wherein Ais an optionally substituted 5- to 14-membered heterocyclic group, etc.; Xis &#x2014;O&#x2014;, &#x2014;S&#x2014;, etc.; Yis an optionally substituted Caryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and Tis a group represented by the following general formula: (wherein Eis a single bond or &#x2014;N(R)&#x2014;, Rand Reach independently represent a hydrogen atom, an optionally substituted Calkyl group, etc. and Zrepresents a Calkyl group, a Calicyclic hydrocarbon group, a Caryl group, etc.)],

A compound represented by the general formula: wherein Xrepresents a nitrogen atom or a group represented by the formula &#x2014;CR&#x2550;; Xrepresents a nitrogen atom or a group represented by the formula &#x2014;CR&#x2550;; Y represents an oxygen atom or the like; Rrepresents a Calkoxy group, an optionally substituted Caryloxy group, a group represented by the formula &#x2014;NRRor the like; Rrepresents a hydrogen atom, an optionally substituted Calkyl group, or the like; R, R, R, R, R, R, Rand Reach independently represent a hydrogen atom, a halogen atom, an optionally substituted Calkyl group, or the like; Rrepresents a group represented by the formula &#x2014;NRRor the like; and Rand Reach independently represent a hydrogen atom, an optionally substituted Calkyl group, or the like, a salt thereof, or a hydrate of the foregoing.

The present invention discloses compounds and compositions of formula (I): having inhibitory activity on activation of STAT6, wherein X represents quinoline, isoquinoline, quinazoline or imidazopyridine; Y represents phenyl, piperazine, pyridine, thiophene, thiazole, oxathiazole or oxathiadiazole; and variables Z, n, R, R, Rand Rare as defined in the claims.

Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof

Sulfonamide-containing heterocyclic compounds

Piperidine compound and pharmaceutical composition thereof

Sulfonamide-containing indole compounds

Growing community of inventors

Ibaraki, Japan

Junichi Kamata