Kyowa Hakko Kogyo Co., Ltd.

Kyowa Hakko Kirin Co., Limited

Kyowa Hakko Kabushiki Kaisha

Junichi Ikeda

Kazuhiro Kubo

Fumio Suzuki

Hiroaki Hayashi

Hiroshi Sano

Katsuhiko Ando

Isao Kawamoto

Shunji Ichikawa

Yuzuru Matsuda

Takeshi Kuroda

Mayumi Yoshida

Tomoyuki Kanda

Masako Kurokawa

Mika Nozawa

Shinichiro Toki

Provided are therapeutic and/or preventive agents for migraine which comprise, as an active ingredient, a compound having a selective adenosine Areceptor antagonistic activity or a pharmaceutically acceptable salt thereof; therapeutic and/or preventive agents for migraine which comprise, as an active ingredient, a compound having a selective adenosine Areceptor antagonistic activity, which has an affinity for the adenosine Areceptor 10 times or higher than that for the adenosine Areceptor, or a pharmaceutically acceptable salt thereof; and the like.

Therapeutic agent for migraine

A hexitol derivative represented by formula (I) ##STR1## wherein R represents hydrogen, unsubstituted or lower alkyl-substituted cycloalkyl, lower alkenyl, lower alkoxy, lower alkanoyl, piperidyl or ##STR2## wherein each of m and n independently represents an integer of 0 to 3; each of X, Y and Z independently represents hydrogen, lower alkyl, lower alkoxy, lower alkanoyl, lower alkanoyloxy, hydroxyl, halogen or nitro or a pharmaceutically acceptable salt thereof.

Hexitol derivatives

A compound of formula (I): ##STR1## wherein R.sub.1 represents hydrogen, hydroxy or acetoxy and R.sub.2 represents hydroxy or acetoxy.

Bioxanthracene derivatives

Disclosed is a hexitol derivative represented by the formula (I): ##STR1## wherein Q represents a formula selected from the group consisting of ##STR2## wherein a represents NH, O or S;

Hexitol derivatives having vasodilative activity

Growing community of inventors

Shizuoka, Japan

Junichi Ikeda