Japan Tobacco Inc.

Yoshitomi Pharmaceutical Industries, Ltd.

Junichi Haruta

Mutsuyoshi Matsushita

Hiromasa Hashimoto

Kazuhiko Sakuma

Yoshihiro Watanabe

Itsuo Uchida

Katsuyoshi Hara

Akihiro Yasuda

Akira Saito

Noboru Furukawa

Koretake Anami

Kunio Iwata

Hiroaki Hari

An amide compound of the formula (I):&#x2003;wherein R is amino and the like, A is alkylene and the like, X is O, S and the like, M is arylene and the like, R, R, Rand Rare H, hydroxy and the like, Ris H, alkyl and the like, m is an integer of 0-6, Ris an optionally substituted aryl and the like, and Ris H, an optionally substituted alkyl and the like, a pharmaceutically acceptable acid addition salt thereof and a pharmaceutical containing same as an active ingredient. The amide compounds exhibit superior suppressive effects on cytokines directly or indirectly involved in inflammations, such as IL-8, IL-1, IL-6, TNF-&#x3b1;, GM-CSF and the like, and are useful for the prophylaxis and treatment of rheumatic diseases, arthritis due to gout and the like.

Amide compounds and use of the same

Amide compounds and use thereof

Heterocyclic aromatic oxazole compounds and use thereof

Oxazole derivatives of the formula (I) ##STR1## wherein one of R and R.sub.1 is a methylsulfonylphenyl, an aminosulfonylphenyl or an alkylaminosulfonylphenyl, and the other is a cycloalkyl having 5 to 7 carbon atoms which is optionally substituted by lower alkyl, a thienyl optionally substituted by lower alkyl or halogen atom or a furanyl optionally substituted by lower alkyl or halogen atom, and R.sub.2 is a lower alkyl, and pharmaceutically acceptable salts thereof. The oxazole derivatives and pharmaceutically acceptable salts thereof have superior antipyretic action, analgesic action, anti-inflammatory action, and particularly, selective inhibitory action on cyclooxygenase-2 (COX-2), and are expected to be useful as an antipyretic agent, an analgesic agent and an anti-inflammatory agent with less side-effects such as disorders in the digestive tract.

Oxazole derivatives and use thereof

Cyclohexene derivative and method of producing the same

Novel peptide derivatives of the following formula ##STR1## wherein each symbol is as defined in the specification, pharmaceutically acceptable acid addition salts thereof and analogous copounds thereof. Since the derivatives and their pharmaceutically acceptable acid addition salts of the present invention possess stronger actions on central nervous system (e.g. antagonistic action against hypothermia, locomotor stimulant action, signal reflex stimulant action), they are of use as a therapeutic medicament for central nervous disorders such as impaired consciousness, depression, hypomnesia, the like in association association with schizophrenia, melancholia, senile dementia, sequelae of cerebrovascular disorders, head trauma, epilepsy and spinocerebellar degeneracy.

Histidyl peptide derivatives

Growing community of inventors

Takatsuki, Japan

Junichi Haruta