Kyowa Hakko Kirin Co., Limited

Dicerna Pharmaceuticals, Inc.

Junichi Enokizono

Takeshi Kuboyama

Tomoyuki Naoi

Toshihiko Ishii

Nobuhiro Yagi

Akihiro Tokunaga

Kentarou Hatanaka

The present invention provides a composition for suppressing the expression of a KRAS gene, comprising a lipid particle containing, as a drug, a double-stranded nucleic acid having an antisense strand having a sequence of bases complementary to the sequence of at least 19 continuous bases of any one KRAS gene's mRNA of sequence Nos. 1 to 3; and a cationic lipid represented by the following formula (I): wherein  

RNAi pharmaceutical composition for suppressing expression of KRAS gene

An object of the present invention is to provide a composition for suppressing expression of a target gene, and the like. A composition comprising an RNA-encapsulated liposome, wherein the RNA contains a sequence consisting of 15 to 30 contiguous bases of a target gene mRNA (hereinafter, sequence X) and a base sequence (hereinafter, complementary sequence X') complementary to the sequence X, 1 to 90% of all sugars binding to the bases of the sequence X and the complementary sequence X&#x2032; being ribose substituted by a modifying group at 2&#x2032; position, and the lipid particle being capable of reaching a tissue or an organ containing an expression site of the target gene is provide.

Composition for suppressing expression of target gene

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Shizuoka, Japan

Junichi Enokizono