Zhejiang Hisun Pharmaceutical Co., Ltd.

Junhui Zhou

Hua Bai

Yue Zhang

Hegeng Wei

Yanghui Guo

Yingqiu Wu

Qingfeng Cai

Yili Ding

Lingwei Bai

Fei Long

Shibao Yang

The present invention relates to a disaccharide intermediate and a synthesis method thereof, relates to the chemical pharmaceutical field, and more specifically relates to a method for preparing a disaccharide segment of a key intermediate for chemically synthesizing heparin and heparinoid compounds. Disclosed are a new disaccharide intermediate and three methods for synthesizing the disaccharide intermediate, that is, compounds of a formula (4) and glucopyranose protected by different anomeric carbon are made to react in the presence of an active agent, to obtain the disaccharide intermediate. According to the technical solutions of the present invention, synthetic raw materials are easy to obtain, have a mild reaction condition, and are suitable for industrialized production.

Disaccharide intermediate and synthesis method thereof

The present invention relates to a process of a chemically synthetic drug, and in particular, to a new intermediate of a heparin pentasaccharide and a preparation method thereof. The process has high reaction efficiency, and an easy reaction operation. The reaction intermediate is easy to be purified, and is appropriate for an industrialization production.

Preparation of new intermediate of heparin pentasaccharide and preparation method thereof

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Zhejiang, China

Junhui Zhou