California Institute of Technology

Washington University

Junhui Shi

Lihong V Wang

Konstantin Maslov

George Macones

Molly Stout

Yuan Qu

Methodius Tuuli

Chiye Li

Peinan Zhao

Peng Hu

In various aspects, a photoacoustic endoscopic probe and methods for measuring a hydration of a connective tissue in vivo using the photoacoustic endoscopic probe are disclosed.

Photoacoustic near-infrared spectroscopic endoscopy

The present disclosure describes a fast-scanning optical-resolution photoacoustic (fsOR-PAE) endoscope for imaging vasculature within tissues in vivo that includes an ultrasonic transducer and a scanning mirror within a lumen of an elongate casing. The scanning mirror is configured to direct the laser pulses from the pulsed laser source to a focal spot outside the casing in a scanning pattern via an imaging window formed in the casing. The scanning mirror is further configured to direct a plurality of photoacoustic signals from the focal spot to the ultrasonic transducer via the imaging window.

Transvaginal fast-scanning optical-resolution photoacoustic endoscopy

Apparatus and methods for measuring infrared absorption of a sample that includes delivering a pulse of infrared radiation to a region of the sample, delivering pulses of radiation of a shorter wavelength than infrared radiation to a sub-region within the region, and using one or more properties of the induced photoacoustic signals to create a signal indicative of infrared absorption of the sub-region of the sample.

Enhanced-resolution infrared photoacoustic microscopy and spectroscopy

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Pasadena, CA, United States of America

Junhui Shi