Conforma Therapeutics Corporation

Receptos, Inc.

Junhua Fan

Lin Zhang

Marcus F Boehm

Adam Richard Yeager

Junko Tamiya

Srinivas Rao Kasibhatla

Marco Antonio Biamonte

Lawrence C Fritz

Marcos Steinberg

Kevin Hong

Jiandong Shi

Philip Turnbull

Jean-Yves Le Brazidec

Sean Konrad McHugh

Kevan Grant

Tom Fowler

Yang Tran

Francis J Burrows

Hanae Benelkebir

Raffaele Pasceri

Maria Ieva

Compounds are provided having the structure of the following Formula I: where R, R, R, Rand Rare as defined herein. Pharmaceutical compositions comprising such compounds, as well as methods related to their manufacture and use, are also provided.

CXCR3 receptor agonists

Ansamycins and methods of preparing and using the same are described. At least some of these ansamycins exhibit one or more of improved aqueous formulation ability, chemical stability, and bioavailability. Some of the derivatives described are dimers. These and others described can include one or more solubilizing groups that have expected merit in rendering the overall compounds useful as drugs and prodrugs.

Ansamycins having improved pharmacological and biological properties

Novel purine compounds of Formula I. and tautomers, pharmaceutically acceptable salts, and prodrugs thereof, wherein X is S, S(O), or S(O); and O is selected from alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl, and heterocyclic, all optionally substituted, are described, as are pharmaceutical compositions comprising the same, complexes comprising the same, e.g., HSP90 complexes, and methods of using the same.

Purine analogs having HSP90-inhibiting activity

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San Diego, CA, United States of America

Junhua Fan