Sutro Biopharma, Inc.

Celgene Corporation

Leland Stanford Junior University

Junhao Yang

Ryan Stafford

Aaron Sato

Heather Stephenson

Christopher D Thanos

Alice Yam

Christopher James Murray

John Lee

James Robert Swartz

Ronald Levy

Avinash Gill

Xiaofan Li

Abigail Yu

Alexei M Voloshin

Shoshana Levy

Stephanie Armstrong

Gregg Kanter

Christopher J Murray

The present disclosure relates to antibodies that selectively bind to B-cell maturation antigen (BCMA) and its isoforms and homologs, and compositions comprising the antibodies. Also provided are methods of using the antibodies, such as therapeutic and diagnostic methods.

Anti-BCMA antibodies and treatment methods

Provided herein are compositions, methods and uses involving antibodies that specifically bind to human CD47. Also provided are uses and methods, such as therapeutic methods, diagnostic methods, and methods of making such antibodies.

Anti-CD47 antibodies and uses thereof

The present disclosure provides modified proteins that are capable of being cleaved by the protease OmpT1. The proteins can be modified in an exposed surface motif to incorporate OmpT1 cleavage sites. Also provided are nucleic acids encoding the modified proteins, bacterial cells that express the modified proteins, and cell free synthesis systems containing modified RF1. The disclosure further provides methods for reducing the deleterious activity of a modified protein in a cell free synthesis system by contacting the modified protein with OmpT1. Also provided are methods for reducing RF1 competition at an amber codon in the cell free synthesis system, and methods for expressing a protein in the cell free synthesis system. The modified proteins of the invention can be used to increase the yield of proteins having non-natural amino acids incorporated at an amber codon.

Proteolytic inactivation of select proteins in bacterial extracts for improved expression

Provided herein are antibodies that selectively bind to Tim-3 and its isoforms and homologs, and compositions comprising the antibodies. Also provided are methods of using the antibodies, such as therapeutic and diagnostic methods.

Anti-Tim-3 antibodies, compositions comprising anti-Tim-3 antibodies and methods of making and using anti-Tim-3 antibodies

Provided herein are antibodies that selectively bind to PD-1 and its isoforms and homologs, and compositions comprising the antibodies. Also provided are methods of using the antibodies, such as therapeutic and diagnostic methods.

Anti-PD-1 antibodies, compositions comprising anti-PD-1 antibodies and methods of using anti-PD-1 antibodies

Bacterial immunity proteins are utilized to increase immune response to an antigen of interest.

Immunogenic protein constructs

Growing community of inventors

Palo Alto, CA, United States of America

Junhao Yang