Institute of Pharmacology and Toxicology Academy of Military Medical Sciences Pla China

Beijing Molecule Science and Technology Co., Ltd.

Chinese Pla General Hospital

Institute of Pharmacology and Toxicology Academy of Military Medical Science P.l.a. China

Peking University

Academy of Military Medical Sciences

Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.l.a.

Institute of Pharmacology and Toxicology Medical Sciences P.l.a. China

Institute of Pharmacology and Toxicology Academy of Millitary Medical Sciences P.l.a. China

Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.l.c. China

Institute of Pharmacology and Toxicology Accademy of Military Medical Sciences P.l.a. China

Beijing Molecule Science Technology Co., Ltd.

Hunan Nanxin Pharmaceutical Co., Ltd.

Junhai Xiao

Song Li

Wu Zhong

Zhibing Zheng

Lili Wang

Xinbo Zhou

Xingzhou Li

Yunde Xie

Xiaokui Wang

Guoming Zhao

Hongying Liu

Hao Cui

Long Long

Wei Li

Xin Li

Wei Chen

Juan Liu

Hongliang Wang

Kunlun He

Ruiyuan Cao

Yanqun Zeng

Guoliang Hu

Xian Wei Zhang

Chunlei Liu

Jie Wang

Ruijun Li

Cheng Xu

Jie Tang

Gang Cheng

Fei Xie

Zhong Wu

Xuejun Zhu

Mingming Zhao

Shuang Cao

Aihua Nie

Hui Qi

Jing Ma

Dian Xiao

Guangqiang Xia

Cuifang Lin

Chengmai Ruan

Ying Wang

Yang Zhang

Yao Liu

Jing Su

Jing Yan Ma

Bing Zhang

Yanming Wang

Bing Li

Hua Chen

Qi Sun

Ping Liu

Hongqiang Wang

Jie Bai

Feifei Li

Liuhong Yun

Dan Jiang

Beifen Shen

Dan Han

Dalong Ma

Hongxia Wang

Changbin Guo

Zihe Rao

Xinghai Ma

Hongwei Gong

Xiancheng Jiang

Zhibing Zhen

Wuhong Pei

Songcheng Yang

Cuiling Shu

Shiyong Fan

Haoming Luo

Shengqian Yang

Xiaoye Zhang

Xiaomei Ling

Meina Li

Enquan Xu

Boqun Lyu

Fangyuan Cao

Kunluu He

Ruijin Li

Xiaoqian Xu

Hua Guan

Libao Xu

Yanbo Yang

Guochao Liao

Dalong MA

The present application relates to a linker containing arylnitro, an antibody-drug conjugate the linker and use of the linker, as well as a pharmaceutical composition comprising the antibody-drug conjugate and use of the antibody-drug conjugate for treatment and/or prevention of a disease

Linker containing arylnitro, antibody-drug conjugate containing linker and use of linker

The present invention provides a compound of a general formula I, a stereomeride, pharmaceutically acceptable salt or a solvate thereof, a preparation method thereof, and usages in preparing medicines for preventing and/or treating diseases or symptoms caused by drug-resistant tumors or drug-resistant bacteria and in preparing medicines for preventing and/or treating diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and infection. Preferably, the diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and infection are diseases or symptoms caused by a heat shock protein 70 (Hsp70). The compound in the present invention is used for overcoming a difficult problem of drug resistance of tumors, improves the effect of tumor treatment, and provides a new medical strategy for clinical tumor treatment. 

Piperidine carboxamide compound, preparation method, and use thereof

The present invention pertains to field of pharmaceutical chemicals, and relates to thiazole inner salt compounds, preparation methods and uses thereof. Specifically, the present invention relates to a compound of Formula I, hydrates or pharmaceutically acceptable salts thereof. The compound of Formula I of the present invention is a potent cross-linking protein cleavage agent, has a stable structure, good physical and chemical properties, and good pharmacological activities, and is suitable for large scale production to obtain samples with stable, controllable and reliable quality, thereby being suitable for pharmaceutical development. 

Thiazole inner salt compounds, and preparation methods and uses thereof

Disclosed in the present invention is a compound of Formula (I), a geometric or optical isomer, a pharmaceutically acceptable salt, a solvate or a polymorph thereof. Also disclosed in the present invention is a composition comprising the compound of Formula (I), the geometric or optical isomer, the pharmaceutically acceptable salt, the solvate or the polymorph thereof. Also disclosed in the present invention is a use of the compound of Formula (I), the geometric or optical isomer, the pharmaceutically acceptable salt, the solvate or the polymorph thereof in the treatment of a disease or disorder such as a hypoglutamatergic condition, a neurodegenerative disease or respiratory depression, particularly in the treatment of a disease or disorder associated with AMPA receptor. 

Brain-targeting prodrug for AMPA receptor synergist, and pharmaceutical applications thereof

The present invention relates to a 2,3-epoxy succinyl derivative, a preparation method and a use thereof, in particular, the present invention relates to a compound represented by Formula (1), a racemate or an optical isomer thereof, a solvate thereof, or a pharmaceutically acceptable salt thereof. The compound according to the present invention has good inhibitory activity and/or selectivity against cathepsin, especially Cathepsin B, can be used in the treatment of multiple diseases associated with cathepsin, for example, osteoporosis, rheumatoid arthritis and osteoarthritis that are associated with Cathepsin K, Ebola virus infection, a degenerative disease and an autoimmune disease that are associated with Cathepsin L, S, especially Cathepsin B-related tumor diseases, such as gastric cancer, cervical cancer, lung cancer, breast cancer, prostate cancer, bladder cancer, colon cancer, neuroglioma, and melanoma. 

2,3-epoxy succinyl derivative, preparation method and use thereof

The present invention relates to a compound represented by Formula I, a racemate or optical isomer thereof, or a pharmaceutically acceptable salt, a solvate or a hydrate thereof, a pharmaceutical composition comprising the compound, and a use thereof in the manufacture of a medicament for preventing and/or treating a disease or disorder associated with a viral infection. 

4-oxo-4,5-dihydrothiazole derivative, preparation method and use thereof

The invention belongs to the technical field of medicines. In particular, the invention relates to a thiazideamide derivative compound or a pharmaceutically acceptable salt or solvate thereof, a pharmaceutical composition comprising the compound or a pharmaceutically acceptable salt or solvate thereof, a method for preparing the compound or a pharmaceutically acceptable salt or solvate thereof, and a use of the compound or a pharmaceutically acceptable salt or solvate thereof. For example, the compound or a pharmaceutically acceptable salt or solvate thereof according to the invention can be used to prevent and/or treat a neurodegenerative disease or a neuropathic disease caused by a physical trauma or a related disease.

Thiazideamide derivative and use thereof

The present invention pertains to the field of pharmaceutical chemicals, and relates to a substituted acethydrazide derivative, preparation method and use thereof; preferably, relates to a compound of Formula I or a pharmaceutically acceptable salt thereof. The compound of the present invention or a pharmaceutically acceptable salt thereof can effectively inhibit proline hydroxylase, stabilize HIF-&#x3b1;, particularly HIF-1&#x3b1;, and has potency in the manufacture of a medicament for treatment and/or prophylaxis and/or adjuvant therapy of anemia, acute ischemic reperfusion injury. 

Substituted acethydrazide derivative, preparation method and use thereof

The invention relates to tizoxanide phosphate or alkane sulfonate compounds represented by Formula I, and pharmaceutically acceptable salts thereof, isomers thereof, hydrates thereof or solvates thereof, and pharmaceutical applications of the compounds. 

Tizoxanide phosphate and alkane sulfonate and pharmaceutical applications thereof

The present invention pertains to the field of pharmaceutical chemicals, and relates to a rapamycin derivative of Formula I, and a preparation method, pharmaceutical composition and use thereof. The compounds of the present invention overcome the defects of rapamycin in terms of water solubility and metabolic properties, and some of the compounds have an in vitro anti-tumor activity superior to rapamycin, have less toxicity to normal cells than rapamycin, and have very good druggability. 

Rapamycin derivative, and a preparation method, pharmaceutical composition and use thereof

The invention relates to a tizoxanide carbamate compound of Formula I and a pharmaceutically acceptable salt, a hydrate or a solvate thereof, and their pharmaceutical use. 

Tizoxanide carbamate and pharmaceutical use thereof

The invention relates to a homoserine lactone derivative of Formula I, preparation method and use thereof. The compound has an effect of regulatory of bacterial quorum sensing, and is useful for preventing and/or treating a disease caused by infection of a bacterium 

N-sulfonyl homoserine lactone derivatives, preparation method and use thereof

The present invention relates to a compound of formula (I), a stereomeride, pharmaceutically acceptable salt, a solvate or an N-oxide thereof, a medicine composition comprising the compound, a method for preparing the compound, and a usage of the compound in treating diseases related to Hsp70. The diseases are preferably selected from tumors, neurodegenerative diseases, and allogeneic transplantation rejection and infection. 

N,N' substituted piperidinamine compounds, and preparation method and usage thereof

The invention relates to a compound of formula I, and a preparation method and use thereof. The compound has a bacterial quorum-sensing regulatory effect, and can be used for prevention and/or treatment of a disease caused by a bacterial infection. 

Bacterial quorum sensing regulator and medical use thereof

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Beijing, China

Junhai Xiao