Lg Chemical Ltd.

Jung Kwon Yoo

Jong Sung Koh

Jong Hyun Kim

Sun Hwa Lee

In Ae Ahn

Seong Gu Ro

You Seung Shin

Hyun Sung Kim

Tae Hwan Kwak

Hyun Il Lee

Hyun Ho Chung

Won Hee Jung

Tae Saeng Choi

Kwi Hwa Kim

Shin Wu Jeong

Jin Ho Lee

The present invention relates to novel imidazole derivatives which show an inhibitory activity against farnesyl transferase, pharmaceutically acceptable salts or isomers thereof and pharmaceutical compositions comprising such imidazole derivatives. More particularly, the present invention relates to intermediate compounds which are used in the preparation of the imidazole derivatives of the invention. Related processes also are disclosed.

Imidazole derivatives having an inhibitory activity for farnesyl transferase and process for preparation thereof

The present invention relates to a novel imidazole derivative represented by formula (1) which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof, in which A, n and Y are defined in the specification; to a process for preparation of the compound of formula (1); to intermediates which are used in the preparation of the compound of formula (1): and to a pharmaceutical composition comprising the compound of formula (1) as an active ingredient.

The present invention relates to a novel imidazole derivative represented by formula (1) which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof, in which A, n,and Y are defined in the specification; to a process for preparation of the compound of formula (1); to intermediates which are used in the preparation of the compound of formula (1); and to a pharmaceutical composition comprising the compound of formula (1) as an active ingredient.

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Daejeon, South Korea

Jung Kwon Yoo