Korea Research Institute of Bioscience and Biotechnology

Jung Hwa Lim

Dong-Soo Im

Cho-Rok Jung

Kyung-Sun Hwang

Mi Young Son

Kyung Sook Chung

Cho Rok Jung

Myung Jin Son

Kyung Hee Noh

Hyun Mi Kang

The present disclosure provides a biomimetic cell culture apparatus that mimics interactions among organs in a human body. The present disclosure includes a plurality of culture units for culturing cells, a conduit for connecting the plurality of culture units to each other to form a circulating path, a pump unit disposed on the conduit for forming a flow in culture medium such that the culture medium circulates through the plurality of culture units, and an agitating module for agitating the plurality of culture units.

Biomimetic cell culture apparatus and cell culture system comprising the same

The present invention relates to the E2UCP-VHL interaction and the uses thereof, more precisely a method for increasing or reducing VHL activity or level by regulating UCP activity or level to inhibit cancer cell proliferation or metastasis or to increase angiogenesis. The inhibition of UCP activity is accomplished by any UCP activity inhibitor selected from a group consisting of a small interfering RNA (RNAi), an antisense oligonucleotide, and a polynucleotide complementarily binding to mRNA of UCP, a peptide, a peptide mimetics and an antibody, and a low molecular compound. In the meantime, the increase of angiogenesis is accomplished by the following mechanism; UCP over-expression is induced by a gene carrier and thus endogenous VHL is reduced, leading to the stabilization of HIF-1&#x3b1; which enhances VEGF activation based on the HIF-1&#x3b1; stabilization. The method for regulating UCP activity or level results in the increase or decrease of VHL activity or level, so that it can be applied to the development of an anticancer agent and an angiogenesis inducer.

Method for therapeutic angiogenesis

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Daejeon, South Korea

Jung Hwa Lim