Daewoong Pharmaceutical Co., Ltd.

Il Dong Pharmaceutical Co., Ltd.

Jung-eun Park

Jung Ho Kim

Gunhee Kim

Jin Hee Lee

Jeong-Geun Kim

Hong Chul Yoon

Keuk-Chan Bang

Kyung Mi An

Changmok Oh

Changhee Hong

Da Hae Hong

Te-ik Sohn

Yearin Jun

Jae Eui Shin

Woo Jin Jeon

Min Whan Chang

Kyeojin Kim

Sung Wook Kwon

In-Gyu Je

Yeongran Yoo

Ji Hye Choi

Eun Hye Jang

A-rang Im

Jin Ah Jeong

Joon-Seok Park

Jaeho Heo

Myong Jae Lee

Wol-Young Kim

Yeon-Jung Park

Youn-Jung Yoon

Min-June Shim

Disclosed are novel compounds of Chemical Formula 1, optical isomers of the compounds, and pharmaceutically acceptable salts of the compounds or the optical isomers. The compounds, isomers, and salts exhibit excellent activity as GLP-1 receptor agonists. In particular, they, as GLP-1 receptor agonists, exhibit excellent glucose tolerance, thus having a great potential to be used as therapeutic agents for metabolic diseases. Moreover, they exhibit excellent pharmacological safety for cardiovascular systems.

GLP-1 receptor agonist and use thereof

The present disclosure relates to a novel phenylpyridine derivative represented by Chemical Formula 1 and a pharmaceutical composition comprising the same, and the compound according to the present disclosure can be usefully used for the prevention or treatment of autoimmune diseases or cancers.

Phenylpyridine derivative and pharmaceutical composition comprising the same

The present invention relates to 4-aminopyrazolo[3,4-d]pyrimidinylazabicyclo derivatives and pharmaceutical compositions containing the same, wherein the 4-aminopyrazolo[3,4-d]pyrimidinylazabicyclo derivatives and pharmaceutical compositions containing them not only have BTK inhibitory activity but also has remarkably high selectivity for the inhibitory activity of BTK vs. ITK, and thereby can be usefully used for the prevention or treatment of autoimmune diseases or cancers as BTK inhibitors.

4-aminopyrazolo[3,4-d]pyrimidinylazabicyclo derivatives and pharmaceutical composition comprising the same

Growing community of inventors

Gyeonggi-do, South Korea

Jung-eun Park