Raphas Co., Ltd.

Yonsei University

Prolagen Co., Ltd.

Jung Dong Kim

Tae Hyung Kim

Seong Jin Kim

Do Hyeon Jeong

Hong Kee Kim

Yang Gi Lee

So Hyun Park

Jung Hyun Bae

Joo Han Lee

Kwang Hoon Lee

DongChul Shin

Booyong Lee

Yongyoun Hwang

Miroo Kim

Eun Jin An

Moon Su Lee

Ju Young Jin

Hyungil Jung

Beom Joon Kim

Seo Hyeong Kim

Jung U Shin

Ji Hye Kim

Keun Ho Lee

A method of manufacturing a microneedle includes selecting and providing a microneedle material whose viscosity/elastic modulus measured for each shear rate using a viscoelasticity measuring equipment falls in a range between a predetermined upper limit and a predetermined lower limit, and manufacturing the microneedle using the microneedle material by an extension process.

Method for testing suitability of microneedle material suitable for manufacture employing elongation process, and microneedle manufacturing method comprising same

The present invention relates to a composition for preparing a microneedle, a soluble microneedle, and a microneedle percutaneous patch comprising the soluble microneedle. A soluble microneedle contained in a microneedle percutaneous patch of the present invention has a high drug loading capacity and excellent strength and thus may contain an effective amount of donepezil or a pharmaceutically acceptable salt thereof even with a small area of the microneedle. Accordingly, the present invention is economical and produces a lower level of skin irritation.

Microneedle percutaneous patch containing donepezil

A manufacturing device for a microneedle includes an upper plate stage, a lower plate stage disposed in horizontally parallel with the upper plate stage, a rotating device configured to rotate and move the upper plate stage over the lower plate stage, and a first cylindrical type actuator configured to vertically move the lower plate stage in a state in which the upper plate stage has been rotated and moved over the lower plate stage by the rotating device. The first cylindrical type actuator may upwardly and downwardly move so as to be able to stretch a viscous composition in a vertical direction in a state in which a contacting to the viscous composition is performed, wherein the viscous composition is applied on both of a patch sheet seated on the upper plate stage and a patch sheet seated on the lower plate stage, or is applied on one of them.

Manufacturing device for micro-needle

The present disclosure relates to a method for manufacturing a microneedle enabling product quality and efficiency in production to be improved by reducing the time needed for spotting a viscous material. The method for manufacturing a microneedle, according to the present disclosure, comprises the steps of spotting a viscous material on a plurality of spots on a film by supplying the viscous material to the upper surface of the film by means of a plurality of through-holes provided on an injection plate, elongating the viscous material spotted on the film; and coagulating the elongated viscous material.

Method for manufacturing microneedle

A manufacturing method of a microstructure includes providing a patch manufacturing sheet formed in a state in which a bottom layer is exposed on an upper part thereof; providing the patch manufacturing sheet on a first process substrate and a second process substrate; spotting a viscous composition at a plurality of positions spaced apart from each other on the bottom layer of the patch manufacturing sheet provided on only the first process substrate, or provided on both of the first process substrate and the second process substrate; contacting the patch manufacturing sheet provided on the second process substrate or the viscous composition to the viscous composition spotted on the patch manufacturing sheet provided on the first process substrate; moving relatively the second process substrate with respect to the first process substrate to stretch the viscous composition and to coagulate the stretched viscous composition; and cutting the coagulated viscous composition.

Manufacturing method of microstructure

Growing community of inventors

Seoul, South Korea

Jung Dong Kim