Syntex (u.s.a.) Inc.

Cellegy Pharmaceuticals Inc.

American Home Products Corporation

Cellergy Pharmaceuticals, Inc.

Jung-Chung Lee

Charles E Lee

Thomas P Parks

Stephen A Berry

Paul J Jarosz

Charles Lee

Vivien Mak

Glenn J Samuels

Richard A Runkel

Shamim Pushpala

A dispensing device includes a hollow body coupled to a pump mechanism having a dip tube, and to a follower piston. A well provided in the piston is generally larger in diameter than the dip tube to allow fluid in the chamber to flow down into the well as the dip tube enters the well to facilitate fluid removal after a significant portion of the fluid has been removed. In some aspects, the well walls and dip tube end are substantially conical shaped with the well walls substantially parallel to the dip tube end or having a greater angle relative to the axis of the dip tube

Taper well meter dose pump

Compositions and methods for the treatment of anorectal disorders are provided in which certain combinations of NO donors, PDE inhibitors, superoxide (O ) scavengers, &bgr;-adrenergic agonists, cAMP-dependent protein kinase activators, &agr; -adrenergic antagonists, L-type Ca channel blockers, estrogens, ATP-sensitive K channel activators and smooth muscle relaxants are used.

Compositions and methods for the treatment of anorectal disorders

This invention relates to coating formulations for coating sustained-release drug implants. The coating formulations are capable of formulations are capable of forming a porous film coat over a biologically active agent to provide a release of the active agent at a constant rate over a prolonged period of time. The pore forming agent is used in the formulation of the invention in the amount effective to regulate the release of a biologically active compound at a desired rate. Preferably, the effective amount of the pore forming agent provides long term delivery of the active agent. The invention also provides an improved implant for the sustained administration of a biologically active compound suitable for subcutaneous implantation. The invention also relates to methods for making and using the formulation and the implant of the invention.

Polymeric microporous film coated subcutaneous implant

Mycophenolate mofetil and mycophenolic acid can be conveniently manufactured into high dose oral formulations by the hot melt filling of a supercooled mycophenolate mofetil or mycophenolic acid liquid into a pharmaceutical dosage form. High dose oral pharmaceutical formulations and manufacturing methods therefor are disclosed.

High dose formulations of mycophenolate mofetil and mycophenolic acid

Mycophenolate mofetil, mycophenolic acid, and ranolazine can be conveniently manufactured into high dose oral formulations by the hot melt filling of a supercooled mycophenolate mofetil, mycophenolic acid, or ranolazine liquid into a pharmaceutical dosage form. High dose oral pharmaceutical formulations and manufacturing methods therefor are disclosed.

High dose ranolazine formulations

High dose formulations

A sustained release, reservoir-type subcutaneous implant device for the sustained administration to a subject of a biologically active compound comprises:

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San Jose, CA, United States of America

Jung-Chung Lee