Sk Chemicals Co., Ltd.

Pacific Corporation

Jung Bum Yi

Young Ho Park

Jin Kyu Choi

Jin Kwan Kim

Yung Hyup Joo

Kyung Min Lim

Keun Ryu

Yeon Su Jeong

Jee Woo Lee

Hyeung Geun Park

Young Ger Suh

Uh Taek Oh

Yong-Baik Cho

Hee Doo Kim

Joo Hyun Moh

Joo Hyon Kim

Hae In Rhee

Young-Ho Park

Hyun Jung Lee

Jae-Sun Kim

Song Seok Shin

Ju Young Lee

Bong-Yong Lee

Hun-Taek Kim

Jung-Hoon Oh

Chang-Kyun Han

Nam Ho Kim

Hyun Ju Koh

Wie-Jong Kwak

Ki-Wha Lee

Nam Kyu Lee

Shin Chung

Sung-hoon Park

Je Ho Ryu

Keun-Ho Ryu

Key An Um

Min-Soo Noh

So Yoon Lee

Sang-hwan Kang

Jun-Yong Ha

Do Seung Kum

Chang Hoon Lee

Yong-Hyuk Kim

In Ho Jung

Ok Hui Park

Sun Young Kim

Young Im Oh

Jae Yoon Jung

Young Joo Byun

Ji Young Kim

Seon Hwa Kang

Ki Won Joung

Yong Sil Lee

Hun Seung Yoo

Hyung Ook Kim

Young Hoon Choi

Taek Su Kim

Hoe-chul Jung

Key-An Um

Keun Ho Ryu

The present invention relates to a herbal drug composition for cartilage protection comprising plant extracts of Clematis Radix, Trichosanthis Radix, and Prunellae Spica and an optimal content of rosmarinic acid to: (i) alleviate pains; (ii) inhibit the acute/chronic inflammation, platelet/whole blood aggregation, immunocyte (B-lymphcyte and T-lymphcyte) proliferation, inflammation-inducing enzyme activities, and enzyme activities associated with degradation of joint tissue; (iii) scavenge activity of toxic active oxygen radicals; and (iv) further provide excellent cartilage protection activity to be effectively used as an anti-inflammatory agent with analgesic effects, blood circulation enhancer, arthritis therapeutic agent and cartilage protective.

Herbal drug composition for cartilage protection

2-pyridyl substituted imidazoles of the formula (I) as shown in claim, are provided, which are useful in the treatment of diseases mediated by ALK5 or ALK4 inhibitors or both.

2-pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors

The present invention relates to novel thiourea derivatives as a modulator for vanilloid receptor (VR) and the pharmaceutical compositions containing the same. As diseases associated with the activity of vanilloid receptor, pain acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fervescence, stomach-duodenal ulcer, inflammatory bowel disease and inflammatory diseases can be enumerated. The present invention provides a pharmaceutical composition for prevention or treatment of these diseases.

Thiourea derivatives and the pharmaceutical compositions containing the same

The invention relates to novel pyridine derivatives having an inhibitory effect on production of cytokines, which are involved in inflammatory responses, thus suggesting its usefulness as therapeutic agents for treating diseases related to inflammation, immune, chronic inflammation as well as an agent having an anti-inflammatory and analgesic effect. Further, this invention relates to a method of manufacturing the same and a pharmaceutical composition containing the same.

Pyridine derivatives, a process for their preparation and a pharmaceutical composition containing the same

The present invention relates to thiourea compounds and the pharmaceutical compositions containing the same, and particularly, to novel thiourea compounds as an antagonist against vanilloid receptor (VR) and the pharmaceutical compositions thereof. As diseases associated with the activity of vanilloid receptor, pain, acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fervescence, stomach-duodenal ulcer, inflammatory bowel disease and inflammatory diseases can be enumerated. The present invention provides a pharmaceutical composition for prevention or treatment of these diseases.

Thiourea compounds and the pharmaceutical compositions containing the same

The present invention provides a novel class of 4,5-diaryl-3(2H)-furanone derivatives, which inhibit strongly and selectively COX-2 over COX-1. They are useful to treat inflammation, inflammation-associated disorders, and COX-2 mediated diseases.

4,5-diaryl-3(2H)-furanone derivatives as cyclooxygenase-2 inhibitors

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Suwon-si, South Korea

Jung Bum Yi