Immunex Corporation

Amgen Inc.

June R Eisenman

Dirk M Anderson

Kenneth H Grabstein

Charles Rauch

Victor Fung

Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.

Method of treating cancer by administering an epithelum-derived T-cell factor

Polynucleotides encoding epithelium-derived T-cell factor and uses thereof

Antibodies to epithelium-derived T-cell factor

Nucleic acid sequences which encode biologically active EMF, expression vectors which direct the expression of ETF, ETE polypeptides, antibodies which specffically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.

Method of treatment with epithelium derived T-cell factor

Epithelium-derived T-cell factor antibodies

Method for treating or preventing gastrointestinal disease with

Epithelium-derived T-cell factor

There is disclosed a mammalian epithelium-derived T-cell factor (EFT) polypeptide, derivatives thereof, DNA sequences, recombinant DNA molecules and transformed host cells that produce ETF polypeptides. More particularly, this invention provides isolated mammalian ETF polypeptides and derivatives thereof that regulate events in T-lymphocyte proliferation.

DNA encoding epithelium-derived T-cell factor

Growing community of inventors

Seattle, WA, United States of America

June R Eisenman