Shenzhen Zinwi Bio-Tech Co., Ltd

Other

Honor Device Co., Ltd.

Cai, Zhou

Jun Zou

Yang Zou

Weixian Luo

Meisen Liu

Zou Cai

Xuehua Mao

The present application provides a preparation method of racemic nicotine, including the following steps: Nicotinyl chloride and methylamine are reacted under alkaline conditions to obtain methylnicotinamide, then condensed with monochloroacetone to obtain N-methyl-N-(2-oxopropyl) nicotinamide, then self-aldol condensed to obtain 1-methyl-5-(pyridin-3-yl)-1,2-dihydro-3H-pyrrol-3-one, and finally reduced to obtain racemic nicotine.

Preparation method of racemic nicotine

A method for preparing chiral synthetic nicotine includes the following steps: Step S1. condensing nicotinic acid ester and γ-butyrolactone under the action of alkaline condensate in organic solvent I to obtain the first mixture; Step S2. performing a ring-opening reaction to the first mixture obtained in Step S1 by adding an acidic substance to obtain a second mixture; Step S3. separating 4-chloro-1-(3-pyridine)-1-butanone from the second mixture obtained in Step S2, reacting with chiral tert-butyl sulfinamide to obtain chiral N-(4-chloro-1-(pyridin-3-yl)butene)-2-methylpropane-2-sulfinamide; Step S4: reacting the chiral N-(4-chloro-1-(pyridin-3-yl) butene)-2-methylpropane-2-sulfenamide with a reducing agent, and then cyclizing under the action of hydrogen halide to obtain a chiral demethylized nicotine; and Step S5: performing methylamination to the chiral demethylized nicotine to obtain a chiral nicotine.

Method for preparing chiral synthetic nicotine

The present application discloses a synthesis method of chiral nicotine from nicotinate and γ-butyrolactone, including the following steps: Step S1: performing condensation under an alkaline condition, and performing ring opening reaction with hydrochloric acid; Step S2: reacting with (+)—B-diisopinocampheyl chloroborane to produce a chiral hydroxyl group; Step S3: performing a chlorination reaction; and Step S4: performing cyclization under an alkaline condition to obtain the chiral nicotine. In the present application, nicotinate and γ-butyrolactone, both cheap and readily available, are used as raw materials, so as to reduce the production cost of (S)-nicotine. (+)—B-diisopinocampheyl chloroborane is used to reduce a carbonyl group of an intermediate to obtain a target chiral center. The (+)—B-diisopinocampheyl chloroborane induces the production of a chiral hydroxyl group, chlorination and cyclization are performed to form chiral (S)-demethylnicotine, and finally amine methylation is performed to obtain (S)-nicotine with photochemical activity.

Synthesis method of chiral (S)-nicotine

A LED light source includes one or more LED light source arrangements, wherein each of the LED light source arrangements includes a LED member having a first light emitting surface and an opposed second light emitting surface, and two fluorescent members on top of the first and second light emitting surfaces of the LED member respectively to retain the LED member in position such that the illumination generated from the LED member is capable of passing through the two fluorescent members from the two light emitting surfaces respectively. The LED light source arrangement provides illumination at an angle greater than 180&#xb0; and direct effective heat dissipation at all sides of the LED member.

LED light source and manufacturing method thereof

A LED light source includes: a LED member having a first light emitting surface and a second light emitting surface opposite of the first light emitting surface, a first fluorescent member provided on the first light emitting surface, and a second fluorescent member provided on the second light emitting surface. The LED light source is capable of greatly increasing the light emitting efficiency and reducing the cost and complexity of the heat dissipation construction.

Growing community of inventors

Guangdong, China

Jun Zou