Marine Biomedical Research Institute of Qingdao Co., Ltd.

Chinese Academy of Fishery Sciences

Qingdao Conson Pharmaceutical Co., Ltd.

Qingdao Haiji Biomedicine Co., Ltd.

Jun Zhao

Chenyang Zhao

Jinbo Yang

Lijuan Wu

Qiaoling Song

Huashi Guan

Yan Zhang

Dan Yao

Jufa Chen

Xiaoyu Jiang

Menglin Yang

Qiufen Li

Yu Tang

Xiaochun Wang

Ximing Xu

Keming Qu

Youjing Lv

Xuzhi Zhang

Dongsheng Ding

Guangli Yu

The present disclosure discloses the use of Tegaserod or a pharmaceutically acceptable salt thereof as a JAK-STAT3 signaling pathway inhibitor and an immunomodulator in the preparation of an anti-tumor drug. Tegaserod and the pharmaceutically acceptable salt thereof show a very excellent inhibitory effect on the growth of various tumor cells in vivo and in vitro, and are expected to be used in the treatment of various cancers.

Use of tegaserod in preparation of anti-tumor drug

An application of a glucan in the preparation of a drug. A β-1,3/1,6-glucan is used for preparing a pharmaceutical composition or formulation. The pharmaceutical composition or formulation can enhance the antitumor effect of immunotherapy, radiotherapy, or chemotherapy, and is used for treating leukopenia and/or thrombocytopenia.

Application of glucan in preparation of drug

An antibiotic susceptibility testing device of gram-negative bacteria, as well as a corresponding method, are discussed. The device has a temperature control unit (including a constant temperature chamber) and a contactless conductivity-based measurement system. Disposable glassy or PVC tubes are used as test vessels for AST. In the performance of AST assay, appropriate kind of liquid medium containing identical amount of target bacterial cells and target antibiotics at different concentrations are loaded into test tubes, following by incubation in the device at a setup temperature. The bacterial growth profile is monitored by collecting the differential values (&#x394;C) of conductivity of liquid medium, which depend on the proliferation of viable cells. Outcome of &#x394;C indicates whether the target bacterial cells are completely inhibited by the test antibiotic or not, enabling the user to judge the value of the minimal inhibitory concentration (MIC) simply.

Device and method for automated antibiotic susceptibility testing of gram-negative bacteria

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Shandong, China

Jun Zhao