The Chinese University of Hong Kong

Jun Yu

Joseph Jao Yiu Sung

Qiaoyi Liang

Ka Kei Wu

Yujuan Dong

Xiaoxing Li

Jao Yiu Joseph Sung

Chi Chun Wong

Francis Ka Leung Chan

Chi-Chun Wong

Kin Fai Cheung

Dabin Liu

Shiyan Wang

Siu Man Simon Ng

Lixia Xu

Simon Siu Man Ng

Qing Li

The present invention provides novel methods for treating and preventing colorectal cancer in a subject by administering a composition comprising β-galactosidase, a bacterial culture capable of producing β-galactosidase, such as anculture, or a fraction of the culture comprising β-galactosidase. A kit useful for such methods is also provided. In addition, the present invention provides a composition for treating or preventing colon cancer.

Therapeutic and prophylactic treatment for colorectal cancer

The present invention provides methods for assessing the likelihood of effectiveness of aspirin-based chemoprotection against colorectal cancer among individuals as well as methods for improving aspirin-based chemoprotection against colorectal cancer. Kits useful for such methods are also provided.

and aspirin chemoprevention of colorectal cancer

The present invention provides for compositions and methods for treating colorectal cancer or for reducing the risk of developing the disease in an individual. More specifically, compositions comprising an effective amount of beneficial bacteria such as, andare provided for the purpose of treating colorectal cancer in a person or for the purpose of reducing a person's risk of later developing colorectal cancer. Corresponding kits and methods are also provided.

Probiotic compositions for treating and preventing colorectal cancer

Provided is a non-invasive method for diagnosing colorectal cancer in a subject by detecting enrichment or reduction of certain bacterial species. A kit and device useful for such methods are also provided. In addition, a method for reducing the risk of colon cancer by regulating the pertinent bacterial species in human colon is also provided.

Fecal bacterial markers for colorectal cancer

The present invention provides novel methods for treating and preventing colorectal cancer in a subject by administering a composition comprising &#x3b2;-galactosidase, a bacterial culture capable of producing &#x3b2;-galactosidase, such as anculture, or a fraction of the culture comprising &#x3b2;-galactosidase. A kit useful for such methods is also provided. In addition, the present invention provides a composition for treating or preventing colon cancer.

The present invention provides a method for providing a diagnosis or prognosis of a non-alcoholic fatty liver disease (NAFLD) in a subject by detecting expression level of the Squalene Epoxidase (SQLE) gene. A kit and device useful for such methods are also provided. In addition, the present invention provides a method for treating NAFLD by suppressing SQLE gene expression or activity.

Squalene epoxidase in the diagnosis and treatment of non-alcoholic fatty liver diseases

The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the REC8 gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating gastric cancer by increasing REC8 gene expression or activity. Lastly, a highly sensitive and accurate detection method is provided for rapid determination of REC8 gene methylation status.

Tumor suppressor REC8 as a biomarker for gastric cancer

The present invention provides methods for assessing the likelihood of effectiveness of chemotherapy such as oxaliplatin treatment in colorectal cancer patients as well as their survival prospect by determining the level of miR-133a in the cancer tissue. A kit useful for such methods are also provided.

miR-133a as a marker for colorectal cancer

The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the SCNN1B gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating gastric cancer by increasing SCNN1B gene expression or activity.

Biomarker SCNN1B for gastric cancer

The present invention provides a method for diagnosing of colorectal cancer in a subject and a method for determining risk of recurrence of colorectal cancer among colorectal cancer patients by detecting overexpression of the RNF6 gene, which in some cases is due to a higher than normal copy number of the genomic sequence of this gene. A kit and device useful for such methods are also provided. In addition, the present invention provides a method for treating colon cancer by suppressing RNF6 gene expression or activity.

Biomarker RNF6 for colorectal cancer

The present invention provides a method for diagnosing and determining prognosis of colorectal cancer in a subject by detecting suppressed expression of the VSTM2A gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating colorectal cancer by increasing VSTM2A gene expression or activity.

Tumor suppressor VSTM2A as a biomarker for colorectal cancer

The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the FOXF2 gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating gastric cancer by increasing FOXF2 gene expression or activity.

Biomarker FOXF2 for gastric cancer

In embodiments the expression or methylation of the TBX5 gene is used as a marker for the presence and prognosis of colon cancer. In further embodiments methods for detecting colon cancer are disclosed as are methods for inhibiting the growth of colon cancer cells.

Marker for colon cancer and method for detecting colon cancer

The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the ZNF545 gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating gastric cancer by increasing ZNF545 gene expression or activity.

Growing community of inventors

Hong Kong, China

Jun Yu