Massachusetts Institute of Technology

Jun Young Yoon

David L Trumper

Minkyun Noh

Daniel Rodion Rathbone

Brij Mohan Bhushan

On-platform pumps provide greater flexibility and design freedom and are a key feature of organs-on-chip platforms. On-platform electromagnetic (EM) pumps have been developed for use with the organ-on-chip platforms. The EM pump uses electrical energy, which may be supplied by a battery, making the pump portable. The EM pump uses an EM actuator having a low energy consumption. The actuator's low energy consumption is achieved by a latching design which requires only a short pulse of energy to switch its state and where springs store some of the actuator kinetic energy, which is then recovered in the reverse stroke. This further reduces the energy consumption of the actuator. Also provided are injection-molded, single-use platforms with onboard diaphragm micro-pumps and various valve and pump geometries. The EM actuators easily integrate with these platforms, demonstrating pumping at a constant flowrate, no measurable temperature rise, and valve sealing against varying back-pressure.

Pumps and hardware for organ-on-chip platforms

High force and low noise linear fine-tooth motors are described herein. Such motors can include armatures having fine teeth separated by narrow slots such that a ratio of a pitch between teeth and a pitch between permanent magnet poles is less than that of a conventional iron-core linear motor. In one embodiment, such a linear motor can include a first component having an armature including a plurality of iron cores surrounded by coil windings, and a second component having a plurality of permanent magnets with alternating polarity. The plurality of iron cores can be spaced apart from one another by an iron core pitch distance and the plurality of permanent magnets can be spaced apart from one another by a permanent magnet pole pitch distance, and a ratio of the iron core pitch to the magnetic pole pitch can be less than 1.33.

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Cambridge, MA, United States of America

Jun Young Yoon