Avigen, Inc.

Other

Jun Yoshida

Peter C Colosi

Gary J Kurtzman

Hideho Okada

Masaaki Mizuno

Kunio Yagi

Nobuko Ohishi

Hideshi Ideno

Keizo Sakuda

Haruyoshi Yajima

It provides a gene-entrapping liposome preparation which can be preserved over a long period of time, and a process for the preparation of the same. The preparation can be prepared by adding an aqueous solution of disaccharide to gene-entrapping liposomes. The frozen preparation can be preserved for 6 months or more at preservation temperature of &minus;20&deg; C., and the preparation shows excellent restoration ability in water and does not show reduction in biological activity. In the case of the lyophilized preparation, it can be preserved for longer time of about 1 year, shows excellent restoration ability in water, and does not show reduction in biological activity.

Gene-entrapped liposomes preparation and process for the preparation thereof

The use of recombinant adeno-associated virus (AAV) virions for the treatment of solid tumors is disclosed. The invention provides for the use of recombinant AAV virions to deliver an AAV vector containing a drug-susceptibility gene and a second gene capable of providing an ancillary effect to solid tumor cells. The second gene can be used to enhance the immunogenicity of the transduced tumor cell. Alternatively, the second gene can be used to provide a tumorstatic effect. The invention also provides for the use of recombinant AAV virions to deliver an interferon gene, or a tumor suppressor gene to provide a therapeutic effect in a transduced tumor cell.

Gene therapy for the treatment of solid tumors using recombinant adeno-associated virus vectors

Adeno-associated virus vectors comprising a first and second nucleic

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Nagoya, Japan

Jun Yoshida